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Carolina Lorena Mascayano Collado

Académico

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

El área de interés es la Bioorgánica, la cuál incluye la síntesis orgánica y ensayos in-vitro frente a blancos enzimáticos involucrados en la vía del ácido araquidónico. Además, se complementan con estudios in-silico por medio de dinámica molecular.

Química, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2006

Académico Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Quimica y Biología

Santiago, Chile

2007 - At present

Académico Full Time

Universidad de Santiago de Chile

Santiago, Chile

2007 - At present

Hasta el momento he dirigido tres Tesis de Doctorado, todas ellas en Química. Actualmente, hay dos estudiantes cursando el Doctorado en Química que están trabajando conmigo. Además, en mi grupo tenemos la realización de tesis de pre-grado en las carreras de Lic en Química, Bioquímica y Química y Farmacia.

Desde al año 2007 , cuando fui contratada en la Universidad de Santiago he asistido a numerosos seminarios y congresos tanto como asistente como de expositor.


Development of novel organometallic sulfonamides with N-ethyl or N-methyl benzenesulfonamide units as potential human carbonic anhydrase I, II, IX and XII isoforms' inhibitors: Synthesis, biological evaluation and docking studies Nocentini, Alessio Article ISI SCOPUS Journal of Inorganic Biochemistry (2024)
Natural pentacyclic triterpenoid as allosteric modulators of human 5-lipoxygenase with potential anti-inflammatory activity Torres-Gonzalez, Simon Article ISI JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2024)
Evaluating the inhibitory activity of ferrocenyl Schiff bases derivatives on 5-lipoxygenase: Computational and biological studies Article ISI SCOPUS Journal of Inorganic Biochemistry (2023)
Fast and Simple Preparation of a Sensor Based on Electrochemically Reduced Graphene Oxide (rGO) for the Determination of Zopiclone in Pharmaceutical Dosage by Square Wave Adsorptive Stripping Voltammetry (SWAdSV) Article ISI SCOPUS Electroanalysis (2023)
Kinetic study of the azo - Hydrazone photoinduced mechanism in complexes with a -Re(CO)3L0/+ core by flash photolysis Gomez, Alejandra; Ferraudi, Guillermo Article ISI SCOPUS Journal of Photochemistry and Photobiology A: Chemistry (2023)
Development of Inclusion Complexes With Relative Humidity Responsive Capacity as Novel Antifungal Agents for Active Food Packaging Article ISI FRONTIERS IN NUTRITION (2022)
Effect of substituents and chain length in amino-1,4-naphthoquinones on glutathione-S-transferase inhibition: molecular docking and electrochemical perspectives: a structure-activity study Faúndez, Mario; Ibacache, Juana A. Article ISI NEW JOURNAL OF CHEMISTRY (2022)
Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand Valenzuela, Beatriz; Aldabaldetrecu, Maialen; Guerrero, Juan Article ISI MOLECULES (2022)
Influence of structure on the electrooxidation rate of six C-4 alcohols Soledad Ureta-Zanartu, Maria; Ilabaca, Jacqueline Article ISI ELECTROCHIMICA ACTA (2022)
Evaluation of cyrhetrenyl and ferrocenyl precursors as 5-lipoxygenase inhibitors - biological and computational studies Navarrete, Elizabeth; Gomez, Alejandra; Mascayano. Carolina Article ISI NEW JOURNAL OF CHEMISTRY (2021)
Prenylated Flavonoids with Potential Antimicrobial Activity: Synthesis, Biological Activity, and In Silico Study Butassi, Estefania; Zacchino, Susana; Mascayano. Carolina Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
A Heterologous Viral Protein Scaffold for Chimeric Antigen Design: An Example PCV2 Virus Vaccine Candidate Lamazares, E; Espinoza F.I. Article ISI SCOPUS VIRUSES-BASEL (2020)
Biological Properties and Absolute Configuration of Flavanones FromCalceolariathyrsifloraGraham Mascayano. Carolina; Osorio, Mauricio Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Design, Synthesis and Biological Evaluation of Ferrocenyl Thiazole and Thiazolo[5,4-d]thiazole Catechols as Inhibitors of 5-hLOX and as Antibacterials against Staphylococcus aureus. Structural Relationship and Computational Studies Gomez, Alejandra; Mascayano. Carolina Article ISI ORGANOMETALLICS (2020)
Development of an Isavirus minigenome system to study the function of the pocket RNA-binding domain of the viral nucleoprotein (NP) in salmon cells Beltran-Pavez C.; VÃ¡squez-MartÃnez Y.; Cortez-San MartÃn M. Article ISI SCOPUS JOURNAL OF FISH DISEASES (2020)
Importance of the electrolyte cation on the non-covalent interactions in the electrooxidation of 1-heptanol on gold in 0.1 M alkali metal hydroxides Article ISI SCOPUS MATERIALS CHEMISTRY AND PHYSICS (2020)
Inhibition of Soybean 15-Lipoxygenase and Human 5-Lipoxygenase by Extracts of Leaves, Stem Bark, Phenols and Catechols Isolated From Lithraea caustica (Anacardiaceae) Munoz-Ramirez, Alejandra; Mascayano-Collado, Carolina; Barriga, Andres Article ISI FRONTIERS IN PHARMACOLOGY (2020)
Study of two isoforms of lipoxygenase by kinetic assays, docking and molecular dynamics of a specialised metabolite isolated from the aerial portion of Lithrea caustica (Anacardiaceae) and its synthetic analogs Torrent-FarÃas C.; Mascayano-Collado C.; UrzÃºa-Moll A. Article ISI SCOPUS PHYTOCHEMISTRY (2020)
Antifungal and physicochemical properties of inclusion complexes based on beta-cyclodextrin and essential oil derivatives Abarca, Romina; Mascayano. Carolina; Ramos Souza Felipe, Fabiana Article ISI SCOPUS FOOD RESEARCH INTERNATIONAL (2019)
Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones Carvajal, Marcela A.; Mascayano. Carolina; Montoya, Margarita Article ISI SCOPUS JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (2019)
Docking, steered molecular dynamics, and QSAR studies as strategies for studying isoflavonoids as 5-, 12-, and 15-lipoxygenase inhibitors Cabezas, F Article ISI SCOPUS JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2019)
New antibacterial and 5-lipoxygenase activities of synthetic benzyl phenyl ketones: Biological and docking studies Toledo, Giannina; Espinosa, Victoria; Montoya-K, Margarita; Mascayano. Carolina Article ISI SCOPUS BIOORGANIC CHEMISTRY (2019)
Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance Mascayano, C; Rojo, LE Article ISI SCOPUS FRONTIERS IN ENDOCRINOLOGY (2018)
Development of a Reverse Genetic System for Infectious Salmon Anemia Virus: Rescue of Recombinant Fluorescent Virus by Using Salmon Internal Transcribed Spacer Region 1 as a Novel Promoter Toro-Ascuy, D; Tambley, C; Beltrán, C; Mascayano, C; Sandoval, N; Olivares, E.; Medina, RA; Spencer, E; Martina M.C.-S. Article ISI SCOPUS APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase Mascayano, C; Espinosa, V; Sepulveda-Boza, S; Hoobler, EK; Perry, S; Díaz, G; Holman, TR Article ISI SCOPUS Chemical Biology & Drug Design (2015)
On the dramatic increase with chain length of the oxidazability of linear saturated aliphatic alcohols on gold in alkaline media Ureta-Zañartu, MS; Mascayano, C; Gutierrez, C Article ISI SCOPUS Electrochimica Acta (2015)
Derivatives of 3H-spiro1-benzofuran-2, 1'-cyclohexanes: immunostimulants for veterinary use Modak,B; Torres, P; Mascayano, C; Torres, R; Urzúa, A; Valenzuela,B Article ISI Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2014)
Derivatives of 3H-spiro1-benzofuran-2, 1'-cyclohexanes: Immunostimulants for veterinary use [Derivados de 3H-espiro1-benzofurano-2, 1'-ciclohexanos: Inmunoestimulantes de uso veterinario] Modak,B; Torres, P; Mascayano, C; Torres, R; Urzúa, A; Valenzuela,B Article SCOPUS Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2014)
COUMARINS OF HAPLOPAPPUS MULTIFOLIUS AND DERIVATIVE AS INHIBITORS OF LOX: EVALUATION IN-VITRO AND DOCKING STUDIES TORRES, RENE; Mascayano. Carolina; Nunez, Carolina; Modak, Brenda; FAINI, FRANCESCA Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2013)
In Vitro Study of Isoflavones and Isoflavans as Potent Inhibitors of Human 12-and 15-Lipoxygenases Mascayano, C; Espinosa, V; Sepulveda-Boza, S; Hoobler, EK; Perry, S Article ISI SCOPUS Chemical Biology & Drug Design (2013)
ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES Mascayano, C; Rivera, Y; Espinosa, V Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2011)
Molecular Phylodynamics and Protein Modeling of Infectious Salmon Anemia Virus (ISAV) Castro-Nallar, E; Martin, MCS; Mascayano, C; Molina, C; Crandall, KA Article ISI SCOPUS BMC Evolutionary Biology (2011)
Sensing different micellar microenvironments with solvatochromic dyes of variable lipophilicity Mascayano, C; Briones, L.; Aliaga, C Article ISI SCOPUS Dyes and Pigments (2011)
Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: A steered molecular dynamics study Mascayano, C; NÃºÃ±ez G.; Acevedo, W; Rezende, MC Article SCOPUS Journal of Molecular Modeling (2010)
Lipophilic contributions to the solvatochromism of analogous betaines Oñate, R; Núñez, G; Domínguez, M; Mascayano, C Article ISI SCOPUS DYES AND PIGMENTS (2009)
Solute-Solvent Interactions in Solutions of Solvatochromic Phenoxides: A Dynamics Simulation Study Mascayano, C; Mendez, C; Núñez, G; Chiang V. Article ISI SCOPUS JOURNAL OF SOLUTION CHEMISTRY (2009)
A structure-activity study of antibacterial diterpenoids Urzúa, A; Mascayano, C; Vásquez, L Article ISI SCOPUS MOLECULES (2008)
Dissection of the components for PIP(2) activation and thermosensation in TRP channels Brauchi, S; Orta, G; Mascayano, C; Salazar, M; Raddatz, N; Urbina, H; Rosenmann, E; Gonzalez-Nilo, F; Latorre, R Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A spectral and molecular dynamics simulation study of beta-cyclodextrin inclusion complexes with solvatochromic dyes derived from barbituric acid Jara, F; Mascayano, C; Tirapegui, C; Urzúa, A Article ISI SCOPUS JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY (2006)
Molecular dynamics simulation of the aqueous solvation shell of cellulose and xanthate ester derivatives Humeres, E; Mascayano, C; Riadi G.; Gonzalez-Nilo, F Article ISI SCOPUS JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2006)
Effects of natural flavones and flavonols on the kinase activity of Cdk5 Zapata-Torres, G; Opazo, F; Salgado, C; Muñoz, JP; Krautwurst, H; Mascayano, C; Sepulveda-Boza, S; Maccioni, RB Article ISI SCOPUS JOURNAL OF NATURAL PRODUCTS (2004)
Biotransformation of natural and synthetic isoflavonoids by two recombinant microbial enzymes Seeger, M; GonzÃ¡lez M; Cámara, B; Muñoz, L; Ponce, E; Mejias, L; Mascayano, C; Vásquez, Y; Sepulveda-Boza, S Article ISI SCOPUS APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2003)
The preparation of new isoflavones Sepulveda-Boza, S; Walizei, GH; Vásquez, Y; Mascayano, C; Mejias, L Article ISI SYNTHETIC COMMUNICATIONS (2001)


Dissecting phosphatidylinositol 4,5-bisphosphate activation and thermosensation in TRP channels Orta, G; Salazar, M; Gonzalez, W; Mascayano, C; Raddatz, N; Rosenmann, E; Gonzalez-Nilo, F; Brauchi, S; Latorre, R Abstract ISI BIOPHYSICAL JOURNAL (2007)


The Thioredoxin Fold Protein (TFP2) from Extreme Acidophilic Leptospirillum sp. CF-1 Is a Chaperedoxin-like Protein That Prevents the Aggregation of Proteins under Oxidative Stress. (vol 25, 6905, 2024) Sievers, Susanne; Zuehlke, Daniela; Jahn, Dieter; Jahn, Martina; Levican, Gloria Correction ISI SCOPUS International Journal of Molecular Sciences (2024)


SYNTHESIS, IN SILLICO AND IN VITRO EVALUATION OF BIARYL ETHANONES, PROPANONES AND PROPENONES AS ANTIVIRULENCE AGENTS AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) CO-INVESTIGADOR Vasquez, Yesseny Proyecto (2024)
Síntesis de derivados de pirazoles y pirazolinas orgánicas y organometálicas como estrategia promisoria para el desarrollo de potentes inhibidores duales de 5-LOX/COX2: ensayos biológicos y estudios in-silico Proyecto (2024)
Design and application of multichannel chemosensors of environmentally relevant analytes; N ́N and NHC transition metal complexes as the building blocks of sensitive and selective platforms. Proyecto (2023)
SEARCH OF NEW PHARMACOPHORES FOR DUAL 5-LOX AND COX-2 INHIBITORS BASED ON CATECHOLIC ISOFLAVAN AND BENZYLPHENYLKETONE DERIVATIVES: BIOLOGICAL AND IN SILICO COMPLEMENTARY APPROACHES Proyecto (2020)

Ricardo Maccioni

DIRECTOR

RESEARCH AND DEVELOPMENT

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

Andres Vega

Director

Departamento de Química

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

ANDRES BARRIGA

Profesional

CEPEDEQ

UNIVERSIDAD DE CHILE

Santiago, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Michael Seeger

Full Professor

Chemistry

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

Francisco Rodríguez

ASSOCIATE PROFESSOR

DEPARTAMENTO DE CIENCIA Y TECNOLOGÍA DE LOS ALIMENTOS

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Maria Aguirre

Professor

Quimica de los materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Maria Soledad Ureta

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Eugenio Spencer

DIRECTOR-INVESTIGADOR

BIOLOGIA

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

fernando godoy

Full Professor

Quimica de los Materiales

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Brenda Modak

Directora Departamento de Ciencias del Ambiente

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Claudia Altamirano

Profesor Titular

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

Cristian Tirapegui

Académico

Universidad Autonoma de Chile

Santiago, Chile

marcela carvajal

INVESTIGADORA ASOCIADA

Química

UNIVERSIDAD TECNICA FEDERICO SANTA MARIA

valparaiso, Chile

Marcelo Cortez

Académico

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Julio Bruna

Academico

Departamento de Ciencias y tecnologia de alimentos

Universidad de Santiago de Chile

Santiago, Chile

Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

Gloria Levican

Académica Profesora Titular

Departamento de Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Mauricio Osorio

Investigador

Química

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

Carolina Aliaga

Profesora Titular

Ciencias de Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

RODRIGO SEGURA

Academico

DEPARTAMENTO DE QUIMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Alvaro Ruiz

Profesor Asociado

Patologia y Medicina Preventiva

UNIVERSIDAD DE CONCEPCION

CHILLAN, Chile

Katy Díaz

Investigador Joven

Química

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

Moisés Domínguez

Assistant professor

Department of Environmental sciences

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

ABEL GUARDA

Full Professor

Food Science and Technology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Javier Echeverría

Profesor Asociado e Investigador

Departamento de Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago de Chile, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Beatriz Cámara

Associate Investigator

Departamento de Química/Centro de Biotecnología Daniel Alkalay

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

Oliberto Sanchez

Associate Professor

Pharmacology

University of Concepción

Concepción, Chile

Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

Rafael Medina

Associate Professor

Pediatrics

Pontificia Universidad Catolica de Chile

Santiago, Chile

MARIA JOSE GALOTTO

Full Professor

Food Science and Technology Department

Universidad de Santiago de Chile

Santiago, Chile

Natalia Raddatz

Daniela Toro

Profesor Asistente

Facultad de ciencias

Universidad de Chile

Santiago, Chile

Eduardo Castro

Associate Professor

Departamento de Microbiología

Universidad de Talca

Talca, Chile

Felipe Opazo

Group Leader

Center for Biostructural Imaging of Neuodegeneration (BIN)

Göttingen, Alemania

Beatriz Valenzuela

Académico Investigador

Facultad de Salud

Universidad Santo Tomás

Viña del Mar, Chile

Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

Eduardo Olivares

Director area biomedicina

Diagnóstico molecular

Bioingentech

santiago, Chile

Waldo Acevedo

Profesor Asociado

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Emilio Lamazares

Profesor Asistente/Investigador

Fisiopatología

Universidad de Concepción

Concepción, Chile

Yesseny Vasquez

Academico

Facultad de Ciencias Médicas

Universidad de Santiago de Chile

Santiago, Chile

Romina Abarca

Académico

Ciencias Animales

Pontificia Universidad Católica de Chile

Santiago, Chile

alejandra vergara

Investigador

Química

Universidad Técnica Federico Santa María

valparaiso, Chile

Ana Méndez

Investigadora Postdoctoral

de Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Carolina Beltrán

Postdoc

Virología

Universidad de Chile

Santiago, Chile

Alejandra Muñoz

Profesor por Hora

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

Michelle Muñoz

Profesor por hora

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

Universidad de Concepción

Concepción, Chile

Erick Flores

Academico

Intituto de Química y Bioquímica

Universidad de Valparaíso

Valparaíso, Chile

Carolina Lorena Mascayano Collado

Líneas de Investigación

Educación

Química, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2006

Experiencia Académica

Académico Full Time

Experiencia Profesional

Académico Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (43)

Abstract (1)

Correction (1)

Proyecto (4)