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Sergio Luis Vargas Munita

Investigador Académico

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Natural history, molecular epidemiology, pathology and imunopathogenesis of Pneumocystis infection in human and animal models

Educación

  •  Especialista en Pediatría, UNIVERSIDAD DE CHILE. Chile, 1986
  •  Medico Cirujano, UNIVERSIDAD DE CHILE. Chile, 1979
  •  Post Doctoral Fellowship Infectious Diseases (5 years), St Jude Children´s Research Hospital. Estados Unidos, 1994

Experiencia Académica

  •   Academico Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1995 - A la fecha

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2011 - A la fecha

Experiencia Profesional

  •   Pediatra, Jefe de Infectología y Neonatología Full Time

    Hospital San Pablo, Coquimbo, IV Region.

    Coquimbo, Chile

    1982 - 1985

  •   Instructor de Pediatría Part Time

    Centro de Diagnóstico Universidad Catolica de Chile

    Santiago, Chile

    1986 - 1989

  •   Post Doctoral Fellow Full Time

    Department of Infectious Diseases, St Jude Children´s Research Hospital

    Memphis, TN, Estados Unidos

    1989 - 1994

  •   Académico Full Time

    Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile

    Santiago, Chile

    1995 - A la fecha

  •   Director Programa de Microbiología y Micología Instituto de Ciencias Biomédicas Full Time

    Universidad de Chile

    Santiago, Chile

    2012 - 2014

  •   Miembro Part Time

    Comité de Etica, Servicio de Salud Metropolitano Norte

    Santiago, Chile

    2005 - 2010

Formación de Capital Humano


Tesis de Doctorado o Especialidad Médica
Dr Patricio Madrid Soto, Tesis de Especialidad Patología 2004
Facultad de Medicina
Pontificia Universidad Católica de Chile

Tesis de Doctorado en Ciencias
Magali Chabé, PhD 2005
University of Lille, Lille, France

Tesis de Doctorado en Farmacología
Pablo Andrés Iturra Montecinos, PhD 2018
Facultad de Ciencias Químicas y Farmacéuticas
Universidad de Chile

Tesis de Doctorado en Farmacología
Andrea Méndez Gálvez, PhD 2019
Facultad de Ciencias Químicas y Farmacéuticas
Universidad de Chile

Tesis de Doctorado en Farmacología
Francisco Pérez Blanco, PhD 2019
Facultad de Ciencias Químicas y Farmacéuticas
Universidad de Chile

Tesis de Magister en Patología Veterinaria
Catherine Sánchez Núñez MSc 2002
Facultad de Ciencias Veterinarias y Pecuarias,
Universidad de Chile

Tesis de Magister en Microbiología
Carolina Ponce Olmos MSc 2005
ICBM, Facultad de Medicina
Universidad de Chile

Tesis de Magister en Microbiología
Paula Bonilla Zamudio MSc 2013
ICBM, Facultad de Medicina
Universidad de Chile

Tesis de Magister en Microbiología
Jaime Astorga Saavedra MSc 2013
ICBM, Facultad de Medicina
Universidad de Chile

Tesis de Magister en Farmacología
Andrea Méndez Gálvez MSc 2015
ICBM, Facultad de Medicina
Universidad de Chile

Tesis de Licenciatura: 10 alumnos.


Difusión y Transferencia


Conferencias o Seminarios invitados

2020 Instituto de Ciencias Biomédicas, Facultad de Medicina Universidad de Chile. “De la pneumonia intraepidémica del SIDA a infección pandémica subclínica”.
https://www.icbm.cl/seminarios-icbm/

2018 Universidad Peruana Cayetano Heredia, Lima, Perú. Formas emergentes de la infección por Pneumocystis mas allá del SIDA y del paciente inmunocomprometido.

2018 International Forum on Medical Parasitology. October 26, Wroclaw, Poland. Lecture: Pneumocystis: Changing views of an atypical fungus in the general population

2018 Invited Professorship: October 24-29. Medical University of Wroclaw, Wroclaw, Poland.

2018 ISHAM (International Society for Human and Animal Mycology) June - July, Amsterdam, The Neatherlands. Round Table presentation: Is Pneumocystis a pathogen for the immunocompetent infant?

2017 Fisabio, University of Valencia, Valencia, Spain: Pneumocystis in infants: a potential public health issue. https://www.youtube.com/watch?v=EXZeWO6wR94

2017 CYTED Lisbon, Portugal: Principal Investigator Progress report for the ERANetLAC European Union Project

2016 University of Laussane, Laussane Switzerland: Pneumocystis in infants.

2016 Instituto de Biomedicina de Sevilla. Congreso Prevention of Infectious Diseases and well-being.

2015 ISHAM (International Society for Human and Animal Mycology) Melbourne Australia: Pneumocystis epidemiology: Colonization versus Infection.

2014 IWOP (International Workshop on Opportunistic Protists) Seville, Spain: Pneumocystis in infants


Premios y Distinciones

  •   Best Poster Award

    St Jude Children´s Research Hospital

    Estados Unidos, 2019

    Premio a Poster Científico Destacado

  •   Fellow IDSA

    Infectious Diseases Society of America

    Estados Unidos, 2005

    Fellow IDSA

  •   Beca Presidente de la República

    MINISTERIO DE PLANIFICACION Y COOPERACION

    Chile, 1989

    Financiamiento para los 3 primeros años de Post-doctoral Fellow en el Departamento de Infectología, St Jude Children´s Research Hospital, Memphis, TN, EEUU.

  •   Visiting Professor

    UNIVERSITY OF WROCLAW

    Polonia, 2018

    Visiting Professor Medical University of Wroclaw, Wroclaw, Poland. Diploma and award.


 

Article (65)

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine
Pneumocystis jirovecii colonization in preterm newborns with respiratory distress syndrome.
Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru
Consensus Multilocus Sequence Typing Scheme for Pneumocystis jirovecii
Optimized DNA extraction and purification method for characterization of bacterial and fungal communities in lung tissue samples
Pneumocystis jirovecii colonisation in pregnant women and newborns in Lima, Peru [Colonización por Pneumocystis jirovecii en mujeres gestantes y recién nacidos en Lima, Perú]
Pneumocystis primary infection in infancy: Additional French data and review of the literature
Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants
Increase in secreted airway mucins and partial Muc5b STAT6/FoxA2 regulation during Pneumocystis primary infection
New DNA Extraction Method for the Detection of Pneumocystis in Lung Tissue Samples of Colonized Individuals
Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection
Early Acquisition of Pneumocystis jirovecii Colonization and Potential Association With Respiratory Distress Syndrome in Preterm Newborn Infants
High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy
Mepolizumab for Eosinophilic COPD
Diagnosis of the primary infection by pneumocystis in autopsy specimens from two infants using lung impression smears (touch preps)
Fungal colonization with Pneumocystis correlates to increasing chloride channel accessory 1 (hCLCA1) suggesting a pathway for up-regulation of airway mucus responses, in infant lungs
Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma
Ventilator associated pneumonia after elective cardiac surgery caused by Pneumocystis jirovecii
Near-Universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants With Sudden Unexpected Death
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre double-blind, placebo controlled trial.
Pneumocystis Colonization in Older Adults and Diagnostic Yield of Single versus Paired Noninvasive Respiratory Sampling
Pneumocystis Colonization Is Highly Prevalent in the Autopsied Lungs of the General Population
Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein
Exploring transplacental transmission of Pneumocystis oryctolagi in first-time pregnant and multiparous rabbit does
Pneumocystis is not a direct cause of sudden infant death syndrome
Sudden Infant Death Syndrome and activating GNAS1 gene mutations
A Randomized, multicenter, double blind, double dummy trial of single dose azithromycin versus high dose amoxicillin for treatment of uncomplicated otitis media.
Detection of Pneumocystis carinii f. sp hominis and viruses in presumably immunocompetent infants who died in the hospital or in the community
Molecular typing of Pneumocystis jirovecii found in formain-fixed paraffin-embedded lung tissue sections from sudden infant death victims
Molecular typing of Pneumocystis jirovecii found in formalin-fixed paraffin-embedded lung tissue sections from sudden infant death victims
Study design questions in treatment of children with acute otitis media.
Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis
High-dose azithromycin versus high-dose amoxicillin-clavulanate for treatment of children with recurrent or persistent acute otitis media
Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the regression and prevention of electrocardiographic abnormalities during 9 years of follow-up
Pregnancy and asymptomatic carriage of Pneumocystis jiroveci
Quinolone treatment for pediatric bacterial meningitis: a comparative study of trovafloxacin and ceftriaxone with or without vancomycin
Distribution of Pneumocystis carinii f. sp. hominis types in the lung of a child dying of Pneumocystis pneumonia
Identification of Pneumocystis carinii in the lungs of infants dying of sudden infant death syndrome
Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants
A randomized, double-blind trial comparing azithromycin and clarithromycin in the treatment of disseminated Mycobacterium avium infection in patients with human immunodeficiency virus
Candidal meningitis in children with cancer
Severe apnea: an early sign of Pneumocystis carinii pneumonia in an HIV-negative infant
Transmission of Pneumocystis carinii disease from immunocompetent contacts of infected hosts to susceptible hosts
Transmission of Pneumocystis carinii DNA from a patient with P-carinii pneumonia to immunocompetent contact health care workers
Association of primary Pneumocystis carinii infection and sudden infant death syndrome
Current status and future challenges for the development of medical mycology in Chile: A local perspective.
Meningitis por Streptococcus pneumoniae resistente a penicilina y cefalosporina
Oral steroids in the induction of experimental Pneumocystis carinii pneumonia
Search for Extrapulmonary Pneumocystis Carinii in an Animal Model
Sensibilidad de Estafilococcus aureus al ingreso y después de tres dias de hospitalización.
LIMITED PERSISTENCE IN AND SUBSEQUENT ELIMINATION OF PNEUMOCYSTIS-CARINII FROM THE LUNGS AFTER PNEUMOCYSTIS-CARINII PNEUMONIA
Uso de Anfotericina B en pacientes pediátricos
CAVITARY LUNG LESIONS IN AN IMMUNOSUPPRESSED CHILD
Azithromycin for treatment of severe Cryptosporidium diarrhea in two children with cancer
Modulating effect of dietary carbohydrate supplementation on Candida albicans colonization and invasion in a neutropenic mouse model
Prophylaxis of Pneumocystis pneumonia (Review)
ASPERGILLUS IN PEPPER
Differences in the antibiotic sensitivity pattern of Coagulase Negative Staphylococci strains from ambulatory patients vs those isolated from inpatients
Amebic disentery in a newborn.
Kawasaki Disease (First Chilean cases)
Rotavirus and acute diarrhea in infancy: comparison of hospitalized and outpatient cases.
Detection of rotavirus in hospitalized and ambulatory infants with acute diarrhea in Santiago de Chile
Multicenter study of birth weight in Chile

BookSection (3)

Neumocystosis
Pneumocystis pneumonia
Infectious Erythema and Human Parvovirus

ConferencePaper (1)

Recent advances and future directions in Pneumocystis pneumonia

Letter (1)

Pneumocystis Is Still Involved in Nonimmunosuppressed Preterm Infants in Europe Reply

Patent (2)

Use of polyols in combating yeast infection and polyol preparations for said use
New method for recognition of Pneumocystis epitopes

Proyecto (14)

Role of the commensal microbiota in lung mucus production
Primary Infection by Pneumocystis in infants: A silent threat to public health
Elucidation of Pneumocystis-induced pathology and sequels in murine models, and evaluation of selected markers of lung damage in autopsied infant lungs
Rol de FoxA2 en la remodelación y respuesta secretora del epitelio respiratorio inducido por la infección de Pneumocystis carinii
Red Iberoamericana sobre Pneumocystosis
Characterization of the mucus-secreting response to Pneumocystis by the respiratory epithelium; a potential co-factor for increased severity of respiratory disease in the immunocompetent host
Emerging forms of Pneumocystis carinii infection and their epidemiological impact in the general population
Primary infection by Pneumocystis in Children
Development of the natural infection rabbit animal model for evaluation of different aspects of the primary infection by Pneumocystis carinii
Infants: An unrecognized reservoir of Pneumocystis carinii
Pathogenic mechanisms in the human primary infection by Pneumocystis carinii and their relevance for sudden infant death syndrome
Pathogenic mechanisms in the human primary infection by Pneumocystis carinii and their relevance for sudden infant death syndrome.
Academic Link between the University of Oxford and the University of Chile
Infants: An unrecognized source of contagion of Pneumocystis carinii for immunocompromised susceptible patients

Review (2)

Importance of tissue sampling, laboratory methods, and patient characteristics for detection of Pneumocystis in autopsied lungs of non-immunosuppressed individuals
Dinámica y patología del barrido mucociliar como mecanismo defensivo del pulmón y alternativas farmacológicas de tratamiento
88
Sergio Vargas

Investigador Académico

Universidad de Chile

Santiago, Chile

6
Carolina Ponce

Lab Manager Lab Infecciones Rspiratorias

Microbiología Y MIcología

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Andrea Méndez

Académico Disciplinar Investigador

Facultad de Ciencias de la Salud

Universidad de Las Américas

Santiago, Chile

2
Caroll Beltrán

Profesor Asistente, Investigador Principal

Medicina

Universidad de Chile, Fac Medicina

SANTIAGO, Chile

1
Jorge Toledo

Investigador

Departamento de Anatomia y Biologia del Desarrollo

Universidad de Chile; Biomedical Neuroscience Institute (BNI)

Santiago, Chile

1
Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Diego Rojas

Académico

ICB

Universidad Autónoma de Chile

Santiago, Chile

1
Fabien MAGNE

Profesor asistante

UNIVERSIDAD DE CHILE

Chile

1
VICTOR GARCIA

Profesor Asistente

Universidad de Chile

Santiago, Chile

1
Catherine Sanchez

Clinical Researcher

Dirección Medica

CLÍNICA LAS CONDES

Santiago, Chile

1
VIVIAN LUCHSINGER

Profesor Asociado

Virología

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA.

Santiago, Chile

1
INES ZULANTAY

PROFESOR ASOCIADO

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA - ICBM

SANTIAGO, Chile

1
Werner Apt

Jefe Laboratorio

Laboratorio de Parasitología

Facultad de Medicina Universidad de Chile

SANTIAGO, Chile