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Alexis Andres Parada Bustamante

PROFESOR ASOCIADO

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

spermatogenesis and male infertility; infertilidad masculina; Male infertility. Y chromosome microdeletions.; Rol of aromatase and estrogens in spermatogenic failure; Estrogens in girls with diabetes mellitus; Andrology; male infertility; steroid hormones; Genetics aspect of Y-chromosome and androgen receptor in male infertility; Estrogens in endocrine patologies; Gene expression in human spermatogenic impairments

doctor en ciencias biologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

profesor asistente Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

2012 - 2020
profesor asociado Full Time

UNIVERSIDAD DE CHILE

medicina

santiago, Chile

2021 - A la fecha

AYUDANTE DE INVESTIGACION Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2001 - 2001
AYUDANTE DE INVESTIGACION Full Time

INSTITUTO MILENIO DE BIOLOGIA FUNDAMENTAL Y APLICADA

SANTIAGO, Chile

2002 - 2003
AYUDANTE DE INVESTIGACION Full Time

INSTITUTO MILENIO DE BIOLOGIA FUNDAMENTAL Y APLICADA

SANTIAGO, Chile

2008 - 2008
POST-DOCTORADO Full Time

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2008 - 2011
PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2012 - 2020
profesor asociado Full Time

universidad de chile

santiago, Chile

2021 - A la fecha

Post-grado

Marzo 2017-Marzo 2021: Dirección de tesis Srta Johanna Carrasco, titulada "Efecto de 2-hidroxiestradiol sobre la capacitación y reacción acrosomal de espermatozoides humanos" para la obtención del grado de Magister en Biología de la reproducción, Universidad de Chile.

Marzo 2017-Marzo 2019: Dirección de tesis Sr Oliver Quintana García, titulada "EFECTO DEL CONSUMO DE MARIHUANA SOBRE LA MORFOLOGÍA ESPERMÁTICA EN HOMBRES CHILENOS Y SU RELACIÓN CON LA FRECUENCIA Y TIEMPO DE CONSUMO" para la obtención del grado de Magister en Morfología, Universidad de Chile.

Marzo 2018-Marzo 2019: Dirección de tesis Sr Gabriel Maldonado Flores, titulada "ALTERACIONES MORFOLÓGICAS ESPECÍFICAS Y NIVELES DE ESPECIES REACTIVAS DEL OXÍGENO EN ESPERMATOZOIDES DE SUJETOS CON INFERTILIDAD PRIMARIA ”" para la obtención del grado de Magister en Morfología, Universidad de Chile.

Pregrado

Marzo 2013-Enero 2014: Dirección de tesis Srta. Cecilia Valencia Robles, titulada "Efectos de hidroxiestradioles y metoxiestradioles sobre la viabilidad de células de Leydig aisladas" para la obtención del título profesional de Biotecnológa, Universidad de la frontera

Mayo 2012-Mayo 2013: Dirección de tesis Srta. Catherine Vargas Núñez titulada "Regulación de la expresión de la enzima Catecol-O-Metiltransferasa por estradiol y testosterona en células de Sertoli aisladas" para la obtención del título profesional de Ingeniero en Biotecnología, Universidad Tecnológica Metropolitana

Marzo 2012-Mayo 2013: Dirección de tesis Sr Cristián Molina Díaz titulada "Efectos de hidroxiestradioles y metoxiestradioles sobre la viabilidad celular y las acciones genómicas de testosterona en células de Sertoli aisladas" para la obtención del título profesional de Ingeniero en Biotecnología, Universidad Tecnológica Metropolitana


Sperm utilize tumor necrosis factor alpha to shut down a 2-methoxyestradiol nongenomic pathway that accelerates oviductal egg transport in the rat Orostica, Maria L.; Reuquen, Patricia; Guajardo-Correa, Emanuel; Parada-Bustamante, Alexis; Cardenas, Hugo; Orihuela, Pedro A. Article ISI REPRODUCTION (2023)
In Vitro Maturation of Fully Grown Mouse Antral Follicles in the Presence of 1 nM 2-Hydroxyestradiol Improves Oocytes' Developmental Competence Merico, Valeria; Zanoni, Mario; Parada-Bustamante, Alexis; Garagna, Silvia; Zuccotti, Maurizio Article ISI REPRODUCTIVE SCIENCES (2021)
Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure=> possible negative implications on Sertoli cells Parada-Bustamante, A; Molina, C; Valencia, C; Flórez, M; Lardone, MC; Argandoña, F; Piottante, A; Ebensperguer, M; Orihuela, PA; Castro, A. Article Andrology (2017)
Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome Lardone, MC; Argandoña, F; Flórez, M; Parada-Bustamante, A; Ebensperger, M; Palma, C; Piottante, A; Castro, A. Article ISI SCOPUS ANDROLOGY (2017)
Prolactin gene expression in the pituitary of rats subjected to vaginocervical stimulation requires Erk-1/2 signaling Reuquen, Patricia; Guajardo-Correa, Emanuel; Oróstica, María L.; Curotto, Constanza; Parada-Bustamante, Alexis; Cardenas, Hugo; Orihuela, Pedro A. Article ISI SCOPUS Reproductive Biology (2017)
2-hydroxyoestradiol and 2-methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells. Valencia, C; Molina, C; Florez, M; Buñay, J; Moreno, RD; Orihuela, PA; Castro, A Article ANDROLOGIA (2016)
Estradiol increases IP3 by a nongenomic mechanism in the smooth muscle cells from the rat oviduct Reuquén P; Orostica ML; Rojas I.; Díaz P; parada Bustamante A; Orihuela, PA Article ISI SCOPUS Reproduction (2015)
Testis development in the absence of SRY: chromosomal rearrangements at SOX9 and SOX3 Vetro, A; Dehghani, MR; Kraoua, L; Giorda, R; Beri, S; Cardarelli, L; Merico, M; Manolakos, E; parada Bustamante A; Castro A.; Radi, O; Camerino, G; Brusco, A; Sabaghian, M; Sofocleous, C; Forzano, F; Palumbo, P; Palumbo, O; Calvano, S; Zelante, L; Grammatico, P; Giglio S; Basly, M; Chaabouni, M; Carella M.; Russo G.; Bonaglia, MC; Zuffardi, O Article ISI SCOPUS European Journal of Human Genetics (2015)
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism Orostica ML; Lopez, J.; Rojas I.; Rocco J.; Díaz P; Reuquén P; Cardenas H.; parada Bustamante A; Orihuela, PA Article ISI SCOPUS REPRODUCTION (2014)
Mating Decreases Plasma Levels of TGF beta 1 and Regulates Myosalpinx Expression of TGF beta 1/TGFBR3 in the Rat Orostica M.L.; Lopez, J.; Zuniga L.M.; Utz D.; Díaz P; Reuquén P; parada Bustamante A; Cardenas H.; Orihuela P.A. Article ISI SCOPUS MOLECULAR REPRODUCTION AND DEVELOPMENT (2014)
Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study Lardone, MC; Marengo, A; parada Bustamante A; Cifuentes L.; Piottante A.; Ebensperger M.; Valdevenito, R; Castro A. Article ISI SCOPUS Journal of Assisted Reproduction and Genetics (2013)
Tumour necrosis factor-alpha is the signal induced by mating to shutdown a 2-methoxyestradiol nongenomic action necessary to accelerate oviductal egg transport in the rat Orostica ML; Zuñiga LM; Utz D.; parada Bustamante A; Velasquez LA; Cardenas H.; Orihuela, PA Article ISI SCOPUS REPRODUCTION (2013)
Analysis of 6 single-nucleotide polymorphisms in the androgen receptor gene in Chilean patients with primary spermatogenic failure parada Bustamante A; Lardone M.C.; Vadevenito R.; Ebensperger M.; Lopez P.V.; Madariaga M.; Piottante A.; Castro A. Article SCOPUS Journal of Andrology (2012)
Androgen receptor CAG and GGN polymorphisms in boys with isolated hypospadias parada Bustamante A; Lardone M.C.; Madariaga M.; Johnson M.C.; Codner, E; Cassorla F.; Castro A. Article ISI SCOPUS Journal of Pediatric Endocrinology and Metabolism (2012)
DAX-1 and DAX-1A expression in human testicular tissues with primary spermatogenic failure Lardone, MC; parada Bustamante A; Ebensperger M.; Valdevenito, R; Kakarieka, E; Martinez, D.; Pommer R.; Piottante A.; Castro A. Article ISI SCOPUS Molecular Human Reproduction (2011)
Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats Rios M.; parada Bustamante A; Velasquez LA; Croxatto HB; Orihuela, PA Article ISI SCOPUS Reproductive Biology and Endocrinology (2011)
A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct parada Bustamante A; Orihuela, PA; Rios M.; Cuevas CA; Orostica ML; Velasquez LA; Villalón MJ; Croxatto HB Article ISI SCOPUS REPRODUCTION (2010)
Androgen Receptor Gene CAG and GGN Repeat Polymorphisms in Chilean Men With Primary Severe Spermatogenic Failure Castro-Nallar, E; Bacallao, K; parada Bustamante A; Lardone, MC; Lopez, PV; Madariaga M.; Valdevenito, R; Piottante A.; Ebensperger M.; Castro A. Article ISI SCOPUS Journal of Andrology (2010)
Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct Orihuela, PA; Zuñiga LM; Rios M.; parada Bustamante A; Sierralta WD; Velasquez LA; Croxatto HB Article ISI SCOPUS REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2009)
Catechol-O-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats parada Bustamante A; Orihuela, PA; Rios M.; Navarrete-Gomez, PA; Cuevas CA; Velasquez LA; Villalón MJ; Croxatto HB Article ISI SCOPUS BIOLOGY OF REPRODUCTION (2007)
Genital Sensory Stimulation Shifts Estradiol Intraoviductal Signaling from Nongenomic to Genomic Pathways, Independently from Prolactin Surges Penarroja-Matutano, C; parada Bustamante A; Orihuela, PA; Rios M.; Velasquez LA; Croxatto HB Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2007)
Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats Orihuela, PA; parada Bustamante A; Zuñiga LM; Croxatto HB Article ISI SCOPUS JOURNAL OF ENDOCRINOLOGY (2006)
Effect of intrauterine insemination with spermatozoa or foreign protein on the mechanism of action of oestradiol in the rat oviduct parada Bustamante A; Orihuela, PA; Croxatto HB Article ISI REPRODUCTION (2003)
Estrogen receptor, cyclic adenosine monophosphate, and protein kinase A are involved in the nongenomic pathway by which estradiol accelerates oviductal oocyte transport in cyclic rats Orihuela, PA; parada Bustamante A; Cortes, PP; Gatica, C.; Croxatto HB Article ISI BIOLOGY OF REPRODUCTION (2003)
Acceleration of oviductal transport of oocytes induced by estradiol in cycling rats is mediated by nongenomic stimulation of protein phosphorylation in the oviduct Orihuela, PA; Croxatto HB Article ISI SCOPUS BIOLOGY OF REPRODUCTION (2001)


A low-dose of 2-hydroxyestradiol is beneficial to mouse oocyte in vitro maturation and developmental competence Merico, V; parada Bustamante A; Zanoni, M; Belli, M; Vigone, G; Rebuzzini, P; Redi, CA; Zuccotti, M; Garagna, S Abstract ISI CHROMOSOME RESEARCH (2015)
INSL3 gene expression is correlated with high levels of serum LH in patients with Sertoli cell-only syndrome Lardone, M; Piottante A.; parada Bustamante A; Argandona, F; Florez, M; Espinoza, A.; Ebensperger M.; Castro A. Abstract ISI HUMAN REPRODUCTION (2013)
TNF-Alpha and TGF-Beta Signaling Cascades are Associated with the Changes in the Mode of Action of Estradiol in the Rat Oviduct Oróstica L.; Zuniga, L.; Utz D.; parada Bustamante A; Croxatto H.; Velasquez L.; Orihuela, PA Abstract ISI BIOLOGY OF REPRODUCTION (2009)
An estradiol metabolite accelerates ovum transport in cyclic rats through non-genomic pathways Ambriz, GD; parada Bustamante A; Orihuela, PA; Ortiz ME; Villalón MJ; Croxatto HB Abstract ISI PLACENTA (2006)
Estrogen receptors in the rat oviduct Orihuela, PA; Zuñiga LM; Rios M.; Llados, C; Sierralta W.; Croxatto HB Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2004)
Protein phosphorylation induced by estradiol in the rat oviduct. Zuñiga LM; Orihuela, PA; Burgess, J; Corthals, GL; Croxatto HB Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2004)
Inositol triphosphate participates in the nongenomic pathway which mediates the effect of estradiol on oviductal egg transport in the rat. Orihuela, PA; parada Bustamante A; Cortes, PP; Zuñiga LM; Croxatto HB Abstract ISI BIOLOGY OF REPRODUCTION (2003)
Estradiol-induced oocyte transport acceleration is mediated by estrogen receptor and nongenomic activation of protein kinase-A signaling pathway in the rat oviduct. Orihuela, PA; parada, a; Croxatto HB Abstract ISI BIOLOGY OF REPRODUCTION (2001)
Estradiol increases rat oviductal protein phosphorylation by a non-genomic action. Orihuela, PA; Croxatto HB Abstract ISI BIOLOGY OF REPRODUCTION (2000)


46,XX/SRY-negative true hermaphrodite parada Bustamante A; Ríos R.; Ebensperger M.; Lardone, MC; Piottante A.; Castro A. EditorialMaterial ISI SCOPUS FERTILITY AND STERILITY (2010)


Alterations in spermatozoa DNA methylation in sons of women with polycystic ovary syndrome (PCOS): a male intergenerational inheritance approach Echiburu, Barbara; "Parada-Bustamante A"; M Maliqueo; Crisosto, N; Montiel J.F. Proyecto (2020)
MOLECULAR STUDY OF LEYDIG CELL FUNCTION IN TESTICULAR TISSUE OF PATIENTS WITH PRIMARY SPERMATOGENIC FAILURE FONDECYT (1120176) Proyecto 2012-2016 Coinvestigador(a)
A DISARRANGED TESTICULAR CONVERSION OF ESTRADIOL TO HYDROXYESTRADIOL AND METHOXYESTRADIOL AS A POSSIBLE FACTOR INVOLVED IN MALE INFERTILITY FONDECYT (11110457) Proyecto 2011-2014 Inv. Responsable


The role of mating in oviduct biology Parada-Bustamante, A; Orostica, ML; Reuquen, P; Zuniga, LM; Cardenas, H; Orihuela, PA Review ISI SCOPUS MOLECULAR REPRODUCTION AND DEVELOPMENT (2016)
Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease parada Bustamante A; Valencia, C; Reuquén P; Díaz P; Rincon-Rodriguez, R; Orihuela, PA Review ISI MINI-REVIEWS IN MEDICINAL CHEMISTRY (2015)