Man

Alexis Andrés Parada Bustamante

PROFESOR ASISTENTE

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


spermatogenesis and male infertility; infertilidad masculina; vejiga neurogénica; Male infertility. Y chromosome microdeletions.; Rol of aromatase and estrogens in spermatogenic failure; Estrogens in girls with diabetes mellitus; Andrology; male infertility; steroid hormones; Genetics aspect of Y-chromosome and androgen receptor in male infertility; Estrogens in endocrine patologies; Gene expression in human spermatogenic impairments

Educación

  •  Ciencias Biológicas, mención ciencias fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Experiencia Académica

  •   profesor asistente Full Time

    UNIVERSIDAD DE CHILE

    MEDICINA

    SANTIAGO, Chile

    2012 - A la fecha

Experiencia Profesional

  •   AYUDANTE DE INVESTIGACION Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    SANTIAGO, Chile

    2001 - 2001

  •   AYUDANTE DE INVESTIGACION Full Time

    INSTITUTO MILENIO DE BIOLOGIA FUNDAMENTAL Y APLICADA

    SANTIAGO, Chile

    2002 - 2003

  •   AYUDANTE DE INVESTIGACION Full Time

    INSTITUTO MILENIO DE BIOLOGIA FUNDAMENTAL Y APLICADA

    SANTIAGO, Chile

    2008 - 2008

  •   POST-DOCTORADO Full Time

    UNIVERSIDAD DE CHILE

    SANTIAGO, Chile

    2008 - 2011

  •   PROFESOR ASISTENTE Full Time

    UNIVERSIDAD DE CHILE

    SANTIAGO, Chile

    2012 - A la fecha

Formación de Capital Humano


Post-grado

Marzo 2017-Presente: Dirección de tesis Srta Johanna Carrasco, titulada "Efecto de 2-hidroxiestradiol sobre la capacitación y reacción acrosomal de espermatozoides humanos" para la obtención del grado de Magister en Biología de la reproducción, Universidad de Chile.

Marzo 2017-presente: Dirección de tesis Sr Oliver Quintana García, titulada "EFECTO DEL CONSUMO DE MARIHUANA SOBRE LA MORFOLOGÍA ESPERMÁTICA EN HOMBRES CHILENOS Y SU RELACIÓN CON LA FRECUENCIA Y TIEMPO DE CONSUMO" para la obtención del grado de Magister en Morfología, Universidad de Chile.

Marzo 2018-presente: Dirección de tesis Sr Oliver Quintana García, titulada "ALTERACIONES MORFOLÓGICAS ESPECÍFICAS Y NIVELES DE ESPECIES REACTIVAS DEL OXÍGENO EN ESPERMATOZOIDES DE SUJETOS CON INFERTILIDAD PRIMARIA ”" para la obtención del grado de Magister en Morfología, Universidad de Chile.

Pregrado

Marzo 2013-Enero 2014: Dirección de tesis Srta. Cecilia Valencia Robles, titulada "Efectos de hidroxiestradioles y metoxiestradioles sobre la viabilidad de células de Leydig aisladas" para la obtención del título profesional de Biotecnológa, Universidad de la frontera

Mayo 2012-Mayo 2013: Dirección de tesis Srta. Catherine Vargas Núñez titulada "Regulación de la expresión de la enzima Catecol-O-Metiltransferasa por estradiol y testosterona en células de Sertoli aisladas" para la obtención del título profesional de Ingeniero en Biotecnología, Universidad Tecnológica Metropolitana

Marzo 2012-Mayo 2013: Dirección de tesis Sr Cristián Molina Díaz titulada "Efectos de hidroxiestradioles y metoxiestradioles sobre la viabilidad celular y las acciones genómicas de testosterona en células de Sertoli aisladas" para la obtención del título profesional de Ingeniero en Biotecnología, Universidad Tecnológica Metropolitana



 

Article (22)

Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells.
Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome
Prolactin gene expression in the pituitary of rats subjected to vaginocervical stimulation requires Erk-1/2 signaling
Estradiol increases IP3 by a nongenomic mechanism in the smooth muscle cells from the rat oviduct
Testis development in the absence of SRY: chromosomal rearrangements at SOX9 and SOX3
Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism
Mating Decreases Plasma Levels of TGF beta 1 and Regulates Myosalpinx Expression of TGF beta 1/TGFBR3 in the Rat
Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study
Tumour necrosis factor-alpha is the signal induced by mating to shutdown a 2-methoxyestradiol nongenomic action necessary to accelerate oviductal egg transport in the rat
Analysis of 6 single-nucleotide polymorphisms in the androgen receptor gene in Chilean patients with primary spermatogenic failure
Androgen receptor CAG and GGN polymorphisms in boys with isolated hypospadias
DAX-1 and DAX-1A expression in human testicular tissues with primary spermatogenic failure
Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats
A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct
Androgen Receptor Gene CAG and GGN Repeat Polymorphisms in Chilean Men With Primary Severe Spermatogenic Failure
Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct
Catechol-O-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats
Genital Sensory Stimulation Shifts Estradiol Intraoviductal Signaling from Nongenomic to Genomic Pathways, Independently from Prolactin Surges
Inositol triphosphate participates in an oestradiol nongenomic signalling pathway involved in accelerated oviductal transport in cycling rats
Effect of intrauterine insemination with spermatozoa or foreign protein on the mechanism of action of oestradiol in the rat oviduct
Estrogen receptor, cyclic adenosine monophosphate, and protein kinase A are involved in the nongenomic pathway by which estradiol accelerates oviductal oocyte transport in cyclic rats
Acceleration of oviductal transport of oocytes induced by estradiol in cycling rats is mediated by nongenomic stimulation of protein phosphorylation in the oviduct

Abstract (9)

A low-dose of 2-hydroxyestradiol is beneficial to mouse oocyte in vitro maturation and developmental competence
INSL3 gene expression is correlated with high levels of serum LH in patients with Sertoli cell-only syndrome
TNF-Alpha and TGF-Beta Signaling Cascades are Associated with the Changes in the Mode of Action of Estradiol in the Rat Oviduct
An estradiol metabolite accelerates ovum transport in cyclic rats through non-genomic pathways
Estrogen receptors in the rat oviduct
Protein phosphorylation induced by estradiol in the rat oviduct.
Inositol triphosphate participates in the nongenomic pathway which mediates the effect of estradiol on oviductal egg transport in the rat.
Estradiol-induced oocyte transport acceleration is mediated by estrogen receptor and nongenomic activation of protein kinase-A signaling pathway in the rat oviduct.
Estradiol increases rat oviductal protein phosphorylation by a non-genomic action.

EditorialMaterial (1)

46,XX/SRY-negative true hermaphrodite

Review (1)

Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease
33
Alexis Parada

PROFESOR ASISTENTE

REPRODUCCION

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

8
Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

6
Raul Valdevenito

Chair

UNIVERSIDAD DE CHILE, HOSPITAL CLINICO UNIVERSIDAD DE CHILE

Santiago, Chile

6
Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

4
Patricia Reuquén

PROFESOR POR HORA

BIOLOGIA

Universidad de Santiago de Chile

SANTIAGO, Chile

3
Daniella Utz

Postdoctorado

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Martha Flórez

Profesional

Medicina

Instituto de Investigación Materno Infantil

Santiago, Chile

1
Pedro Orihuela

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Lidia Zuniga

Profesor Asistente

Biomédico

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
Eduardo Castro

Associate Professor

Center for Bioinformatics and Integrative Biology

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Emanuel Guajardo

Estudiante doctoral

Universidad de Chile

Santiago, Chile