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Francisco Antonio Pérez Bravo

DIRECTOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Epigenetics; Gene Regultation; Metabolisms; Vitamin D; Functional Foods.

Bioquímica , UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1990
Biología Molecular, Universidad Complutense de Madrid. España, 1996
Bioquímica , UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1989

PROFESOR TITULAR Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

2009 - At present
PROFESOR TITULAR Part Time

UNIVERSIDAD DE CHILE

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS (INTA)

SANTIAGO, Chile

1995 - At present
Director Full Time

UNIVERSIDAD DE CHILE

Instituto de Nutrición y Tecnología de los Alimentos (INTA)

Santiago, Chile

2018 - At present

THESIS DIRECTIONS (2015-2020)

1. Bárbara Echiburú López. Magister in Biotechnology. Science Faculty. Universidad de Chile. Tittle: Expression profile of inflammatory markers: IL-6-MCP-1 and adiponectin in adipose tissue of postmenopausal women with polycystic ovary síndrome. Director: Dr. Francisco Pérez-Bravo. January 2015.

2. Carolina Pizarro Acevedo. Magister in Biotechnology. Science Faculty. Universidad de Chile. Tittle: miRNA expression in type 1 diabetic patiens: association with autoimmunity and inflammation. Director: Dr. Francisco Pérez-Bravo. January 2015.

3. Francisca Concha Celume. Magister in Genetics. Medicine Faculty. Universidad de Chile. Title: Methylation patterns of MCP-1 promotor gene in childrens from polycystic ovary síndrome mothers. Director: Dr. Francisco Pérez-Bravo. July 2015.

4. Viviana Arroyo J. Magister in Human Nutrition. Instituto de Nutrición y Tecnología de los Alimentos (INTA). Universidad de Chile. Title: Methylation state in CpG isles of the MCP-1 promotor gene and their correlation with homocistein and folic acid in type 1 diabetic patiens. Director: Dr. Francisco Pérez-Bravo. July 2015.

5. Holguer Santiago Estrella. Magister in Genetics. Medicine Faculty. Universidad de Chile. Title: microRNA - 22 and microRNA-150 expression profile in perypheral mononuclear cells of type 1 diabetic patients and the relationship with autoinmune and clinical charasteristics. Director: Dr. Francisco Pérez-Bravo. November 2015.

6. Lissette Duarte Silva. Magister in Human Nutrition. Instituto de Nutrición y Tecnología de los Alimentos (INTA). Universidad de Chile. Title: microRNA-378 expression profile and IL-6 levels in type 1 diabetic patients with differential body fat composition. Director: Dr. Francisco Pérez-Bravo. August 2017.

7. Karla Bascuñan Gamboa. Phd Nutritional Sciences (Programa Doctorado DOCNUTAL). Universidad de Chile. Doctoral Thesis: miRNAs and inflammation in celiac disease patients. Directors: Dra. Magdalena Araya and Dr. Francisco Pérez-Bravo. May 2017.

8. Alvaro Pérez Bazán. PhD Nutritional Sciences (Programa Doctorado DOCNUTAL). Universidad de Chile. Doctoral Thesis: Effect of zinc suplemmentation in type 2 diabetic patients on glucagón secretion. Directors: Dr. Manuel Ruz and Dr. Francisco Pérez-Bravo. December 2017.

9. Franco González Villar: PhD Candidate Veterinary and Silvoagropecuary Sciences (Programa Doctorado DCSAV). Uiversidad de Chile. Doctoral Thesis: Analysis of hormonal and immunological factors on the canine diabetes mellitus characterization. Director: Dr. Francisco Pérez-Bravo. October 2021.

10. Francisca Concha Celume: PhD Candidate Nutritional Sciences (Programa Doctorado DOCNUTAL). Universidad de Chile. Doctoral Thesis: Intergenerational effects of sucralose and stevia in mice models. Directors: Dr. Martín Gotteland and Dr. Francisco Pérez-Bravo. Thesis in Progress 2020-2022.

Premio Julio Santiago

Eli Lilly Awardee

Uruguay, 2001

Asociación Latinoamericana de Diabetes. Premio al Investigador Joven Destacado
Premio Sociedad Chilena de Endocrinología y Diabetes

Sociedad Chilena de Endocrinología y Diabetes

Chile, 2014

Premio al Investigador Destacado 2014


Sucralose and stevia consumption leads to intergenerational alterations in body weight and intestinal expression of histone deacetylase 3 Concha Celume F, Pérez-Bravo F, Gotteland M. Article NUTRITION (2024)
Amount, stability, and digestibility of carbohydrates after the extrusion process: Impact on the glycemic index of flours commonly consumed in Chile Soto, Claudia Vega; VEGA-SALINAS, CARLOS RAFAEL; Perez-Bravo, Francisco; Mariotti-Celis, Maria Article ISI SCIELO Revista chilena de nutrición (2023)
Childhood Obesity and Plasma Micronutrient Deficit of Chilean Children between 4 and 14 Years Old Castillo-Valenzuela, Oscar; Duarte, Lissette; Arredondo, Miguel; Iniguez, German; Villarroel, Luis; Perez-Bravo, Francisco Article ISI NUTRIENTS (2023)
Redesign of an instant legume soup for older adults with increased micronutrients bioaccessibility and adequate sensory attributes by using encapsulation Arazo-Rusindo, Migdalia; Reano, Geraldine; Perez-Bravo, Francisco; Castillo-Valenzuela, Oscar; Benavides-Valenzuela, Sergio; Zuniga, Rommy N.; Mariotti-Celis, Maria Salome Article ISI LWT-FOOD SCIENCE AND TECHNOLOGY (2023)
Nutritional Status and Serum Levels of Micronutrients in an Elderly Group Who Participate in the Program for Complementary Food in Older People (PACAM) from the Metropolitan Region, Santiago de Chile Arazo-Rusindo, Migdalia Caridad; Zuniga, Rommy N.; Cortes-Segovia, Pablo; Benavides-Valenzuela, Sergio; Perez-Bravo, Francisco; Castillo-Valenzuela, Oscar; Mariotti-Celis, Maria Salome Article ISI NUTRIENTS (2022)
Response to Analysis of serum 25-hydroxyvitamin D levels involves taking into account several confounding factors. Pérez-Bravo F, Arredondo-Olguín M, Castillo-Valenzuela O Article EUROPEAN JOURNAL OF CLINICAL NUTRITION (2022)
The rs483145 polymorphism of MC4R gene is not associated with obesity in the Chilean population: Results of GENADIO study Mardones, Lorena; Parra-Valencia, Esteban; Petermann-Rocha, Fanny; Adela Martinez-Sanguinetti, Maria; Maria Leiva-Ordonez, Ana; Lasserre-Laso, Nicole; Martorell, Miquel; Ulloa, Natalia; Sanhueza, Eduardo; Perez-Bravo, Francisco; Celis-Morales, Carlos; Villagran, Marcelo; ELHOC Epidemiology Lifestyle Hlth Article ISI ENDOCRINOLOGIA DIABETES Y NUTRICION (2022)
Determination of autoantibodies in dogs with diabetes mellitus. González-Villar F, Pérez-Bravo F Article VETERINARY WORLD (2021)
Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population Mardones, Lorena; Petermann-Rocha, Fanny; Martinez-Sanguinetti, Maria Adela; Leiva, Ana Maria; Troncoso-Pantoja, Claudia; Martorell, Miquel; Lasserre, Nicole; Ulloa, Natalia; Perez-Bravo, Francisco; Celis-Morales, Carlos; Villagran, Marcelo Article ISI ARCHIVES OF ENDOCRINOLOGY METABOLISM (2021)
The administration of an extract from Berberis microphylla stimulates energy expenditure, thermogenesis and mitochondrial dynamics in mice brown adipose tissue Ramirez, Luisa A.; Quezada, Javier; Duarte, Lissette; Concha, Francisca; Escobillana, Lucas; Rincon-Cervera, Miguel Angel; Perez-Bravo, Francisco; Elorza, Alvaro A.; Bravo-Sagua, Roberto; Garcia-Diaz, Diego F. Article ISI FOOD BIOSCIENCE (2021)
The FTO rs17817449 Polymorphism is Not Associated With Sedentary Time, Physical Activity, or Cardiorespiratory Fitness: Findings From the GENADIO Cross-Sectional Study Martorell, Miquel; Mardones, Lorena; Petermann-Rocha, Fanny; Adela Martinez-Sanguinetti, Maria; Maria Leiva-Ordonez, Ana; Troncoso-Pantoja, Claudia; Flores, Fernando; Cigarroa, Igor; Perez-Bravo, Francisco; Ulloa, Natalia; Mondaca-Rojas, Daniel; Diaz-Martinez, Ximena; Celis-Morales, Carlos; Villagran, Marcelo; Epidemiology Lifestyle Hlth Outcom Article ISI JOURNAL OF PHYSICAL ACTIVITY & HEALTH (2021)
The treatment with an extract from Calafate (Berberis microphylla) induces transcript and protein expression of molecules involved in thermogenesis and adipocyte browning in adipose tissue from obese mice Duarte, Lissette; Quezada, Javier; Ramirez, Luisa A.; Vasquez, Karla; Orellana, Juan F.; Villanueva, Vanessa; Perez-Bravo, Francisco; Garcia-Diaz, Diego F. Article ISI JOURNAL OF BERRY RESEARCH (2021)
Vitamin D status and obesity in children from Chile Perez-Bravo, Francisco; Duarte, Lissette; Arredondo-Olguin, Miguel; Iniguez, German; Castillo-Valenzuela, Oscar Article ISI EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)
Body fat composition and mir-378 expression profiling in patients with type 1 diabetes Duarte L, García-Díaz D, Pérez-Bravo F. Article Ann Pediatr Endocrinol Metab (2020)
DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS Echiburu, Barbara; Milagro, Fermin; Crisosto, Nicolas; Perez-Bravo, Francisco; Flores, Cristian; Arpon, Ana; Salas-Perez, Francisca; Recabarren, Sergio E.; Sir-Petermann, Teresa; Maliqueo, Manuel Article ISI EPIGENETICS (2020)
A miRNA-Based Blood and Mucosal Approach for Detecting and Monitoring Celiac Disease BascuÃ±Ã¡n K.A.; PÃ©rez-Bravo F.; Gaudioso G.; Vaira V.; Roncoroni L.; Elli L.; Monguzzi E.; Araya M. Article ISI SCOPUS DIGESTIVE DISEASES AND SCIENCES (2019)
Association of rs3751812 polymorphism of the FTO gene with adiposity and metabolic markers in Chilean population. Results of the GENADIO study Mardones, Lorena; Petermann, Fanny; Martínez, María Adela; Leiva, Ana María; Troncoso-pantoja, Claudia; Martorell, Miquel; Ulloa, Natalia; Lasserre, Nicole; Pérez-bravo, Francisco; Celis-Morales, Carlos; Villagrán, Marcelo Article ISI SCOPUS Nutricion Hospitalaria (2019)


El tejido adiposo como órgano endocrino Pérez-Bravo F, Salas-Pérez F BookSection (2022)
ALIMENTOS FUNCIONALES Perez, Francisco; Atalah, E.; Gotteland, Martin BookSection (2016)
NUTRIGENOMICA: NUTRIENTES Y EXPRESION GENICA Perez, Francisco BookSection (2016)
VITAMINA D Y CALCIO (FOSFORO Y MAGNESIO) Perez, Francisco BookSection (2016)
VITAMINA E Y K Diego F García-Díaz; Perez, Francisco BookSection (2016)
¿Qué miran y evalúan los editores y revisores de las revistas?. Arredondo M, Pérez F BookSection


NUTRICION Y SALUD RUZ, MANUEL H; Perez, Francisco BookWhole (2016)


Response to Analysis of serum 25-hydroxyvitamin D levels involves taking into account several confounding factors Perez-Bravo, Francisco; Arredondo-Olguin, Miguel; Castillo-Valenzuela, Oscar Letter ISI EUROPEAN JOURNAL OF CLINICAL NUTRITION (2022)


Diseño racional del sistema de administración oral de florotaninos como alternativa para controlar el estado metabólico de los ancianos con sarcopenia o riesgo de sarcopenia María Salomé Mariotti Celis; Francisco Pérez-Bravo Proyecto (2022)
Efecto de la ingesta diaria de una crema de legumbres con bioaccesibilidad controlada de nutrientes y adecuada aceptabilidad sensorial sobre la inflamación, parámetros metabólicos, masa, fuerza y función muscular en adultos mayores Francisco Pérez-Bravo; Zuñiga, Rommy; Salome Mariotti-Celis, Maria; Albala, Cecilia Hortensia; Castillo, Oscar.; Benavides, Sergio; Alviña W, Marcela; Claudia Vega; Cortes, Pablo A Proyecto (2021)
Engineering design of β-lactoglobulin fluid gels as carriers for controlled delivery of polyphenols: effect of microstructure on the in vitro and in vivo oxidative stress and inflammatory response after digestión Rommy Zúñiga Pardo; Troncoso, Elizabeth.; Francisco Pérez-Bravo Proyecto (2020)
Determinación de la exposición fetal y del lactante a edulcorantes no calóricos. Implicancias para el desarrollo de las preferencias para el sabor dulce en la infancia y la ganancia de peso durante el primer año de vida FONIS (18I0062) Proyecto 2019-2020 Coinvestigador(a)
Desarrollo de alimentos saludables con buenos atributos sensoriales para mejorar el estado nutricional del adulto mayor FONDEF (ID17AM0018) Proyecto 2018-2020 Coinvestigador(a)
Prevention of obesity and insulin-resistance in vivo through enhancement of mass and function of brown/beige adipose tissue induced by the consumption of a polyphenol-rich extract from Berberis microphylla FONDECYT (1171550) Proyecto 2017-2020 Coinvestigador(a)
INTERACTION BETWEEN NEGATIVE REGULATION GENES OF T LYMPHOCYTE=> CTLA-4 AND PD-1 ON THE APOPTOTIC EVENTS ASSOCIATED TO TYPE 1 DIABETES PREDISPOSITION FONDECYT (1100075) Proyecto 2010-2013 Inv. Responsable
RELACION ENTRE AUTO-INMUNIDAD Y MUERTE CELULAR PROGRAMADA EN LA DIABETES TIPO 1=> ¿PUEDE LA ASOCIACION ENTRE LOS GENES CTLA-4 Y ANTICUERPOS ANTI-CASPASA-8 RESPONDER ESTA INTERROGANTE?. FONDECYT (7070077) Proyecto 2007-2008 Inv. Responsable
RELACION ENTRE AUTO-INMUNIDAD Y MUERTE CELULAR PROGRAMADA EN LA DIABETES TIPO 1=> ¿PUEDE LA ASOCIACION ENTRE LOS GENES CTLA-4 Y ANTICUERPOS ANTI-CASPASA-8 RESPONDER ESTA INTERROGANTE?. FONDECYT (1060790) Proyecto 2006-2009 Inv. Responsable


Diet therapy in rheumatoid arthritis: A review of the evidence Castillo, Carolina Diaz; Bravo, Francisco Perez Review ISI Revista chilena de nutrición (2023)