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Maria Cristina Theoduloz Lafuente

Planta Profesional

UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Chemistry of Natural Products; Structural modification of natural compounds; Biological activity of natural and semisynthetic compounds; Biological activity of naturally occurring and synthetic compounds; Action mechanisms of bioactive compounds in human cell cultures; Cytotoxicity and antiproliferative activity in human cell cultures

Educación

  •  Licenciado en Biologia, UNIVERSIDAD DE CONCEPCION. Chile, 1981

Experiencia Académica

  •   Planta Profesional Full Time

    UNIVERSIDAD DE TALCA

    Ciencias de la Salud

    Chile

    1989 - At present

Experiencia Profesional

  •   Asistente de investigacion Full Time

    Universidad Nacional de Asuncion

    Asuncion, Paraguay

    1985 - 1988

Formación de Capital Humano


Ivana Patricia Bravo Carrión
Tesis de Doctorado en Ciencias, mención Investigación y Desarrollo de Productos Bioactivos (Universidad de Talca)
Co-tutora: Cristina Theoduloz Lafuente
Tutor: Guillermo Schmeda Hirschmann
Terminada: 2014

Daniela Carolina Valenzuela Briceño
Tesis de Pregrado (Tecnología Médica, Universidad de Talca)
Tutora: Cristina Theoduloz Lafuente
Terminada: 2012

Fernanda Bustamante Troncoso
Tesis de Pregrado (Tecnología Médica, Universidad de Talca)
Tutores: Cristina Theoduloz Lafuente, Guillermo Schmeda Hirschmann
Terminada: 2012

Solange Cádiz Castillo
Tesis de Pregrado (Tecnología Médica, Universidad de Talca)
Tutores: Cristina Theoduloz Lafuente, Guillermo Schmeda Hirschmann
Terminada: 2012

Jesús Rodríguez Rodríguez
Tesis de Pregrado (Tecnología Médica, Universidad de Talca)
Tutora: Cristina Theoduloz Lafuente
Terminada: 2015



 

Article (149)

Arylated analogues of cypronazole: fungicidal effect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations.
Iridoids and polyphenols from chilean Gaultheria spp. berries decrease the glucose uptake in Caco-2 cells after simulated gastrointestinal digestion
Phenolic Composition and alpha-Glucosidase Inhibition of Leaves from Chilean Bean Landraces
Antiglycating Effect of Phenolics from the Chilean Currant Ribes cucullatum under Thermal Treatment
Phenolic composition, antioxidant capacity and α-glucosidase inhibitory activity of raw and boiled Chilean Araucaria araucana kernels
Thermal treatment of phenolics from the Patagonian currant Ribes cucullatum: effects on its antiglycating activity.
Bioactive constituents from South American Prosopis and their use and toxicity.
Effects of gastrointestinal digested polyphenolic enriched extracts of Chilean currants (Ribes magellanicum and Ribes punctatum) on in vitro fecal microbiota.
Iridoids and amino acid derivatives from the Paraguayan crude drug Adenocalymma marginatum (ysypó hu).
Isolation and characterization of secondary metabolites from Gaultheria tenuifolia berries.
Phenolics from the Bolivian Highlands food plant Ombrophytum subterraneum (Aspl.) B. Hansen (Balanophoraceae): antioxidant and α-glucosidase inhibitory activity.
Andean Prumnopitys andina (Podocarpaceae) fruit extracts: characterization of secondary metabolites and potential cytoprotective effect.
Anti-inflammatory effect of polyphenols from Chilean currants (Ribes magellanicum and R. punctatum) after in vitro gastrointestinal digestion on Caco-2 cells.
Antioxidant activity and the isolation of polyphenosls and new iridoids from Chilean Gaultheria phillyreifolia and G. poeppigii berries.
Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs
Effect of simulated gastrointestinal digestion on polyphenols and bioactivity of the native Chilean red strawberry (Fragaria chiloensis spp. chiloensis f. patagonica).
Effect of simulated gastrointestinal digestion on polyphenols and bioactivity of the native Chilean red strawberry (Fragaria chiloensis ssp. chiloensis f. patagonica)
Fabiana imbricata Ruiz et Pav. (Solanaceae), a review of an important Patagonian medicinal plant.
Male sexual enhancers from the Peruvian Amazon.
Patagonian berries as native food and medicine.
Phenolic, oxylipin and fatty acid profiles of the Chilean hazelnut(Gevuina avellana): Antioxidant activity and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes.
Polyphenol composition and (bio)activity of Berberis species and wild strawberry from the Argentinean Patagonia.
Changes in polyphenol composition and bioactivity of the native Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) after in vitro gastrointestinal digestion.
Cholinesterase inhibition activity, alkaloid profiling and molecular docking of Chilean Rhodophiala (Amaryllidaceae).
Colonic fermentation of polyphenols from Chilean currants (Ribes spp.) and its effect on antioxidant activity and metabolic syndrome-associated enzymes.
Effect of polyphenols from wild Chilean currants (Ribes spp.) on the activity of intracellular antioxidant enzymes in human gastric cells.
Inhibition of key enzymes in the inflammatory pathway by hybrid molecules of terpenes and synthetic drugs: in vitro and in silico studies.
Neuroprotective effects of ferruginol, jatrophone, and junicedric acid against Aβ injury in hippocampal neurons.
Oligostilbenoids in Pinot Noir Grape Cane Extract: Isolation, Characterization, Antioxidant Capacity and in vitro Anti-proliferative Effect on Cancer Cells.
Polyphenolic profile and antioxidant activity of meristem and leaves from “chagual” (Puya chilensis Mol.), a salad from central Chile.
Access to new cytotoxic quinone-amino acid conjugates linked through a vinylic spacer from 2- acylnaphthoquinones and methyl 3-aminocrotonate.
Cytoprotective mechanisms mediated by polyphenols from Chilean native berries against free radical-induced damage on AGS cells.
Qualitative and quantitative changes in polyphenol composition and bioactivity of Ribes magellanicum and R. punctatum after in vitro gastrointestinal digestion
The Native Fruit Geoffroea decorticans from the Arid Northern Chile: Phenolic Composition, Antioxidant Activities and In Vitro Inhibition of Pro-Inflammatory and Metabolic Syndrome-Associated Enzymes.
Antioxidant activity and phenolic profiles of the wild currant Ribes magellanicum from Chilean and Argentinean Patagonia.
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae).
Chemical profiling and antioxidant activity of Bolivian propolis.
Phenolics from the Patagonian currants Ribes spp.: Isolation, characterization and cytoprotective effect in human AGS cells.
Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone-Amino Acid Derivatives
Synthesis and cytotoxic activity on human cancer cells of novel isoquinolinequinone-amino acid derivatives.
The Chilean wild raspberry (Rubus geoides Sm.) increases intracellular GSH content and protects against H2O2 or methylglyoxal-induced damage in AGS cells.
Anti-inflammatory activity of Copao (Eulychnia acida Phil., Cactaceae) fruits.
Anti-inflammatory activity of Copao (Eulychnia acida Phil., Cactaceae) fruits.
Antibacterial activity, antioxidant effect and chemical composition of propolis from Región del Maule, central Chile.
Chilean Prosopis Mesocarp Flour: Phenolic Profiling and Antioxidant Activity
Chilean Prosopis Mesocarp Flour: Phenolic Profiling and Antioxidant Activity.
Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma.
Synthesis, antiproliferative and antifungal activities of 1,2,3-triazole-substituted carnosic acid and carnosol derivatives.
Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs.
Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs.
Antioxidant activity and characterization of constituents in copao fruits (Eulychnia acida Phil., Cactaceae) by HPLC-DAD-MS/MSn
Antioxidant activity and characterization of constituents in Copao fruits(Eulychnia acida Phil., Cactaceae) by HPLC-DAD-MS/MS.
Antioxidant effect and characterization of South American Prosopis pods syrup.
Antioxidant effect and characterization of South American Prosopis pods syrup.
Antiproliferative activity and new argininyl bufadienolide esters from the "cururu" toad Rhinella (Bufo) schneideri
Antiproliferative activity and new argininyl bufadienolide esters from the “Cururú” toad Rhinella (Bufo) schneideri.
Gastroprotective Mechanisms of Action of Semisynthetic Carnosic Acid Derivatives in Human Cells
Gastroprotective mechanisms of action of semisynthetic carnosic acid derivatives in human cells.
Synthesis and antiproliferative activity of novel triazole derivatives from dehydroabietic acid.
Synthesis and Antiproliferative Activity of Some Novel Triazole Derivatives from Dehydroabietic Acid
Synthesis and antiproliferative evaluation of new isomeric ellipticine quinones.
Synthesis and antiproliferative evaluation of new isomeric ellipticine quinones.
Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones
Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones
Synthesis, Half-Wave Potentials and Antiproliferative Activity of 1-Aryl-substituted Aminoisoquinolinequinones
Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.
Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds.
1,2,3-Triazole-substituted oleanolic acid derivatives: synthesis and antiproliferative activity.
Dimeric labdane diterpenes: synthesis and antiproliferative effect.
Diterpenylquinone Hybrids: Synthesis and Assessment of Gastroprotective Mechanisms of Action in Human Cells
Diterpenylquinone Hybrids: Synthesis and Assessment of Gastroprotective Mechanisms of Action in Human Cells.
Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines
Synthesis and in vitro antiproliferative activity of new phenylaminoisoquinolinequinones against cancer cell lines.
. Potential gastroprotective effect of novel cyperenoic acid-quinone derivatives in human cell cultures.
Argentinean Amaryllidaceae Wild, a New Renewable Source of Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids.
Biological activities and correlations tendency of electrochemical properties of some indolizino[1,2-b]quinoline derivatives.
New Gastroprotective Labdeneamides from (4S,9R,10R) methyl 18-carboxi-labda-8,13(E)-diene-15-oate.
Synthesis and antitumor evaluation of 6-aryl-substituted benzo j phenanthridine- and benzo gpyrimido4,5-c isoquinolinequinones.
Synthesis and in vitro cytotoxic evaluation of aminoquinones structurally related to marine isoquinolinequinones.
Gastroprotective effect and cytotoxicity of labdeneamides with amino acids.
Gastroprotective Effect of Carnosic Acid Derivatives.
Studies on Quinones. Part 47. Synthesis of novel phenylaminophenanthridinequinones as potential antitumor agents.
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.
Gastroprotective effect of carnosic acid γ-lactone derivatives.
Studies on Quinones. Part 46. Synthesis and in vitro antitumor evaluation of aminopyrimido-isoquinolinequinones.
Synthesis of Lakshminine and Antiproliferative Testing of Related Oxoisoaporphines
Synthesis, Gastroprotective Effect and Cytotoxicity of New Amino Acid Diterpene Monoamides and Diamides
Antiproliferative activity of arborescidine alkaloids and derivatives.
Antiproliferative activity of the diterpenes jatrophone and jatropholone and their derivatives.
Comparison of phenolic composition and antioxidant properties of two native Chilean and one domestic strawberry genotypes.
Gastroprotective effect and cytotoxicity of abietane diterpenes from the Chilean lamiaceae Sphacele chamaedryoides (Balbis) Briq.
Studies on Quinones. Part 45. Novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines.
Synthesis and Antitumor evaluation of 8-phenylaminopyrimido [4,5-c]isoquinolinequinones.
Synthesis and Antitumor Evaluation of Thiophene Analogues of Kigelinone
Analgesic, anti-inflammatory and antioxidant properties of Buddleja globosa, Buddlejaceae.
Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii.
Gastroprotective activity of ferruginol in mice and rats: effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls.
New gastroprotective effect with selective cytotoxicity againstgastric cancer cells.
Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethilene-containing 1,4-napthoquinones.
Studies on Quinones. Part 44. Novel Angucyclinone N-Heterocyclic Analogues Endowed with Antitumoral Activity.
Biotransformation of Jatrophone by Aspergillus niger ATCC 16404.
Biotransformation of Imbricatolic Acid by Aspergillus niger, Cunninghamella echinulata and Rhizopus nigricans Cultures.
Free radical scavengers from Cymbopogon citratus (DC.) Stapf. plants cultivated in bioreactors by the temporary immersion (TIS)-principle.
Free radical scavenging activity and phenolic content in achenes and thalamus from Fragaria chiloensis ssp. chiloensis (f. chiloensis), F. chiloensis ssp. chiloensis (f. patagonica), F. vesca and F. ananassa cv. Chandler.
Free radical scavenging activity and secondary metabolites from in vitro cultures of Sanicula graveolens.
Gastroprotective and cytotoxic effect of semisynthetic ferruginol derivatives.
Gastroprotective effect and cytotoxicity of labdenamides.
Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives.
Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug “yagua rova” (Jatropha isabelli).
Gastroprotective activity of cyperenoic acid derivatives.
Gastroprotective and ulcer healing effect of ferruginol in mice and rats: assessment of its mechanism of action using in vitro models.
Gastroprotective and ulcer-healing activity of oleanolic acid derivatives: in vitro-in vivo relationships.
Studies on Quinones. Part 40. Synthesis and cytotoxicity evaluation of anthraquinone epoxides and isomerization products.
Synthesis and Cytotoxic Activity of Isoquinoline-containing Polycyclic Quinones.
Bioactive Metabolites from the Fungus Nectria galligena, the Main Apple Canker Agent in Chile.
E-cinnamic acid derivatives and phenolics from the Chilean strawberry fruits, Fragaria chiloensis ssp.chiloensis.
Free radical scavengers and antioxidants from Lemongrass (Cymbopogon citratus)(DC.) Stapf.
Gastroprotective activity of a new semisynthetic solidagenone derivative.
Gastroprotective Activity of Sesquiterpene Derivatives from Fabiana imbricata.
Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives.
Gastroprotective and ulcer-healing effect of new solidagenone derivatives in human cell cultures.
Gastroprotective effect and cytotoxicity of natural and semisynthetic labdane diterpenes from Araucaria araucana.
Gastroprotective effect of the Mapuche crude drug Araucaria araucana resin and its main constituents.
Involvement of ethylene in stress-induced expression of the TLC1.1 retrotransposon from Lycopersicon chilense.
Metabolites from Microsphaeropsis olivacea, an endophytic fungus of Pilgerodendron uviferum.
Proximate composition and free radical scavening activity of edible fruits from the argentinian Yungas.
Secondary metabolites from endophytic fungi isolated from the Chilean gymnosperm Prumnopitys andina(Lleuque).
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetycholinesterase inhibitors.
Free radical Scavengers and Antioxidants from Baccharis grisebachii.
Free radical scavengers and antioxidants from Tagetes mendocina.
Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.
Expression of a -endotoxin cry1Ab gene in Bacillus subtilis and Bacillus licheniformis strains that naturally colonize the phylloplane of tomato plants.
Free radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo").
RFLP-PCR identification of endemic Chilean species belonging to genus Rhagoletis.
Biologically active alkaloids and a free radical scavenger from Prosopis species.
Relative toxicity of native Chilean Bacillus thuringiensis strains against Scrobipalpuloides absoluta (Lepidoptera: Gelechiidae).
Biological activity of medicinal plants of Ica (Perú).
Effect of Fabiana imbricata constituents on Rhopalosiphon padi and Heliothis zea.
Specificity and insecticidal activity of chilean strains of Bacillus thuringiensis.
Hypotensive and diuretic effect of Equisetum bogotense and Fuchsia magellanica extracts in rats and micropropagation of E. bogotense.
Chilean potato germplasm with resistance to potato viruses Y and S.
Rutin and scopoletin content and micropropagation of Fabiana imbricata.
The incidence of potato viruses X, Y and S in the Chilota Potato Collection.
Xanthine oxidase inhibitory activity of Chilean Myrtaceae.
Xanthine oxidase inhibitory activity of Paraguayan Myrtaceae.
Preliminary pharmacologycal studies on Eugenia uniflora leaves: xanthine oxidase inhibitory activity.
Pyrrolizidine alkaloid content in some Senecio grisebachii populations.
Pyrrolizidine alkaloids from Senecio brasiliensis populatinos.
Desmidiceas (Saccodermae y Placodermae) de Chile. IV. Demidiaceas del sistema de lagos de la Cordillera del Paine y alrededores.

Abstract (1)

Cytoprotective effects of Chilean wild currants (Ribes spp.) against oxidative stress mediated by enhancing the activity of cellular antioxidant enzymes

ConferencePaper (1)

Ethnopharmacology as a basis for medicinal chemistry studies: combining natural products and semisynthesis for gastroprotective agents

Proyecto (21)

Polyphenols from Chilean native berries as antiglycating agents submitted to thermal treatment conditions: a contribution to decrease deleterious effects mediated by dietary glycotoxins
A metabolomic approach on the health promoting effect of phenolics and saponins from Chilean native beans and squash
Cape Horn International Center for Global Change Studies and Biocultural Conservation (CHIC)
Multidisciplinary studies on bioactive compounds from the Chilean Phaseolus vulgaris L. landraces and their potential effects in the prevention of non-communicable chronic diseases
Phenolic metabolome of Chilean native nuts and seeds: antioxidant activity and inhibitory effect on key enzymes associated with metabolic syndrome.
Metabolomics of Chilean Native Fruits.
Novel hybrid terpene-naphthoquinone gastroprotective compounds: synthesis and assessment of action mechanisms using human cell culture models.
Phenstatin analogues and donor-acceptor naphthoquinones: Synthesis via solar-chemical photo-Friedel-Craft reaction and antitumor evaluation.
Semisynthesis of new gastroprotective labdane diterpenes: structure-activity relationships.
Estudio del mecanismo gastroprotector de diterpenos naturales y hemisintéticos derivados del ferruginol y carnosol, utilizando modelos animales y cultivo de células epiteliales gástricas humanas.
Antioxidantes, antifúngicos y antiparasitarios de Protousnea poepigii, Tagetes mendocina, Usnea florida y Zucccagnia punctata.
Atrapadores de radicales libres e inhibidores enzimáticos de plantas aromáticas y medicinales sudamericanas.
Actividad insecticida de bacterias modificadas del filoplano del tomate como complemento para el control de la plaga “polilla del tomate”.
Determinación sexual en la planta dioica Melandrium album. Identificación de genes involucrados en el programa de diferenciación masculino.
Caracterización de cepas nativas de Bacillus thuringiensis y optimización de la expresión de los genes codificadores de sus -endotoxinas
Análisis, comprensión y manipulación de la respuesta de vegetales al estrés ambiental.
Molecular genetics and breeding for resistance and stress tolerance in potatoes.
Obtención de plantas transformadas que expresen la -endotoxina de cepas locales de Bacillus thuringiensis.
Química, actividad biológica y micropropagación de plantas medicinales mapuches.
Resistencia a virosis en papa: desarrollo de plantas resistentes a los virus PVX, PVY, PVS y PLRV mediante técnicas de cultivo in vitro y biología molecular.
Transformación genética de maíz y caña de azúcar para la obtención de plantas resistentes al ataque de insectos.
160
Maria Theoduloz

Planta Profesional

UNIVERSIDAD DE TALCA

Talca, Chile

5
Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

2
Samanta Thomas

Profesor Titular

Facultad de Farmacia

Universidad de Valparaíso

Valparaíso, Chile

1
Alberto Burgos

Asistente de Investigación

Departamento de investigación

Universidad Nacional de Asunción

San Lorenzo, Paraguay

1
Felipe Jimenez

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

1
Daniel Droguett

Profesor Conferenciante

Estomatología

Universidad de Talca

Talca, Chile

1
Pedro Buc

Profesor titular

Quimica y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
Felipe Avila

Profesor Asociado

UNIVERSIDAD DE TALCA

Talca, Chile

1
Daniel Mieres

Postdoctorante

Instituto de Ciencias Biológicas

Universidad de Talca

Talca, Chile

1
Vicente Castro

Associate Professor

Chemistry

UNIVERSIDAD METROPOLITANA DE CIENCIAS DE LA EDUCACIÓN

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile