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Francisco Jose Salinas Sanhueza

Profesor Asociado

Universidad Austral de Chile

Valdivia, Chile

Genómica funcional, microbiología, genética, biología molecular y optogenética en levaduras.

Doctor en Microbiología, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2011
Licenciatura en Ingeniería en Biotecnología, UNIVERSIDAD DE CHILE. Chile, 2007
Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2008

Postdoctorado Full Time

Université de Nice

Facultad de Medicina

Nice, Francia

2012 - 2014
Postdoctorado Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2014 - 2017

Investigador asociado Full Time

Universidad de Santiago de Chile

Santiago, Chile

2017 - 2019
Profesor Auxiliar Full Time

Universidad Austral de Chile

Valdivia, Chile

2019 - 2024
Profesor Asociado Full Time

Universidad Austral de Chile

valdivia, Chile

2024 - A la fecha

Director de tesis de pregrado: 10 tesis finalizadas.
Co-director de tesis de pregrado: 1 tesis finalizada.
Director de tesis de magister: 2 tesis finalizadas.
Director de tesis de doctorado: 4 tesis en curso.

Mejor trabajo de incorporación

SOCIEDAD DE BIOQUIMICA DE CHILE

Chile, 2019

Premio al mejor trabajo de incorporación de la Sociedad de Bioquímica y Biología Molecular de Chile (SBBMCh).


Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains Fundora, Leyanis; Khaiwal, Sakshi; Salinas, Francisco Article ISI BIOLOGICAL RESEARCH (2023)
The N-Terminal Region of the BcWCL1 Photoreceptor Is Necessary for Self-Dimerization and Transcriptional Activation upon Light Stimulation in Yeast Guerrero, Matias; Ruiz, Diego; Salinas, Francisco Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
A Saccharomyces eubayanus haploid resource for research studies Villegas, Claudia; Salinas, Francisco; Nespolo, Roberto F.; Cubillos, Francisco A. Article ISI Scientific Reports (2022)
Expanding the molecular versatility of an optogenetic switch in yeast Inzunza, Claudia; Toro, Rodrigo; Salinas, Francisco Article ISI FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)
Interactions between Core Elements of the <i>Botrytis cinerea</i> Circadian Clock Are Modulated by Light and Different Protein Domains Salinas, Francisco Article ISI JOURNAL OF FUNGI (2022)
Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast Salinas, Francisco Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
The rise and shine of yeast optogenetics Salinas, Francisco Article ISI YEAST (2021)
Comparison of Phylogenetic Tree Topologies for Nitrogen Associated Genes Partially Reconstruct the Evolutionary History of Saccharomyces cerevisiae Salinas, Francisco Article ISI SCOPUS MICROORGANISMS (2020)
Differential Gene Expression and Allele Frequency Changes Favour Adaptation of a Heterogeneous Yeast Population to Nitrogen-Limited Fermentations Salinas, Francisco Article ISI FRONTIERS IN MICROBIOLOGY (2020)
GTR1 Affects Nitrogen Consumption and TORC1 Activity in Saccharomyces cerevisiae Under Fermentation Conditions Salinas, Francisco Article ISI FRONTIERS IN GENETICS (2020)
Total evidence or taxonomic congruence? A comparison of methods for combining biological evidence Salinas, Francisco Article ISI JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY (2020)
Transcriptional Activity and Protein Levels of Horizontally Acquired Genes in Yeast Reveal Hallmarks of Adaptation to Fermentative Environments Cubillos, Francisco A.; Salinas, Francisco Article ISI FRONTIERS IN GENETICS (2020)
Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation Cubillos, Francisco A.; Salinas, Francisco; Schacherer, Joseph Article ISI SCOPUS PLOS ONE (2019)
Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains Salinas, Francisco Article ISI SCOPUS YEAST (2019)
KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae Salinas, Francisco; Su, Ying Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2019)
Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast Salinas, Francisco; Agosin, Eduardo Article ISI SCOPUS mBio (2018)
GPD1 and ADH3 Natural Variants Underlie Glycerol Yield Differences in Wine Fermentation Tapia, Sebastián M.; Cuevas, Mara; Abarca, Valentina; Salinas, Francisco; Cubillos, Francisco A. Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2018)
Clonal Heterogeneity Influences the Fate of New Adaptive Mutations Vázquez-García, Ignacio; Li, Jing; Fischer, Andrej; Barré, Benjamin; Hallin, Johan; Bergström, Anders; Alonso-Perez, Elisa; Warringer, Jonas; Mustonen, Ville; Liti, Gianni Article ISI SCOPUS Cell Reports (2017)
Optogenetic switches for light-controlled gene expression in yeast Rojas, Vicente Article ISI SCOPUS APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)
Extensive Recombination of a Yeast Diploid Hybrid through Meiotic Reversion Salinas, Francisco Article ISI PLOS GENETICS (2016)
Natural variation in non-coding regions underlying phenotypic diversity in budding yeast Salinas, F.; de Boer, CG; Abarca, V; garcia, v; Cuevas, M.; Araos S.; Martínez C; Cubillos, FA Article ISI SCOPUS Scientific Reports (2016)
Powerful decomposition of complex traits in a diploid model Hallin, Johan; Märtens, Kaspar; Young, Alexander I.; Zackrisson, Martin; Parts, Leopold; Warringer, Jonas; Liti, Gianni Article ISI SCOPUS NATURE COMMUNICATIONS (2016)
RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast Kessi-Pérez E.I.; Araos S.; garcia, v; Salinas, F.; Abarca, V; Larrondo, L.F.; Martínez C; Cubillos, F. A. Article ISI SCOPUS FEMS YEAST RESEARCH (2016)
ATG18 and FAB1 Are Involved in Dehydration Stress Tolerance in Saccharomyces cerevisiae Salinas, Francisco Article ISI PLOS ONE (2015)
Concerted Evolution of Life Stage Performances Signals Recent Selection on Yeast Nitrogen Use Salinas, Francisco Article ISI MOLECULAR BIOLOGY AND EVOLUTION (2015)
A High-Definition View of Functional Genetic Variation from Natural Yeast Genomes Bergstroem, Anders; Salinas, Francisco Article ISI MOLECULAR BIOLOGY AND EVOLUTION (2014)
Mapping Genetic Variants Underlying Differences in the Central Nitrogen Metabolism in Fermenter Yeasts Jara M.; Cubillos, FA; garcia, v; Salinas, F.; Aguilera, O; Liti, G; Martínez C Article ISI PLOS ONE (2014)
High-Resolution Mapping of Complex Traits with a Four-Parent Advanced Intercross Yeast Population Cubillos, FA; Parts, L; Salinas, F.; Bergstrom, A; Scovacricchi, E; Zia, A; Illingworth, CJR; Mustonen, V; Ibstedt, S; Warringer, J; et al. Article ISI SCOPUS Genetics (2013)
Identification of genes related to nitrogen uptake in wine strains of Saccharomyces cerevisiae Contreras, A; garcia, v; Salinas, F.; Urzua, U; Ganga, M.A; Martínez C Article ISI SCOPUS World Journal of Microbiology and Biotechnology (2012)
The Genetic Basis of Natural Variation in Oenological Traits in Saccharomyces cerevisiae Salinas, F.; Cubillos, F. A.; Soto, D; garcia, v; Bergstrom, A; Warringer, J; Ganga, M.A; Louis E.J.; Liti, G; Martínez C Article ISI SCOPUS PLOS ONE (2012)
Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis Salinas, F.; Ravanal C.; garcia, v; Carrasco, C.; Martínez C; Saavedra J. Article ISI SCIELO SCOPUS ELECTRONIC JOURNAL OF BIOTECHNOLOGY (2011)
Revealing the genetic structure of a trait by sequencing a population under selection Cubillos, Francisco A.; Jain, Kanika; Salinas, Francisco; Molin, Mikael; Quail, Michael A. Article ISI GENOME RESEARCH (2011)
Genomic and phenotypic comparison between similar wine yeast strains of Saccharomyces cerevisiae from different geographic origins Salinas, F.; Mandakovic, D; Urzua, U; Massera, A; Miras, S; Combina M.; Martínez C Article ISI SCOPUS JOURNAL OF APPLIED MICROBIOLOGY (2010)
Taqman real-time PCR for the detection and enumeration of Saccharomyces cerevisiae in wine Salinas, F.; Garrido, D.; Ganga A.; Veliz, G; Martínez C Article ISI SCOPUS FOOD MICROBIOLOGY (2009)
POLYMERASE CHAIN REACTION CONFIRMATORY METHOD FOR MICROBIOLOGICAL DETECTION OF BRETTANOMYCES BRUXELLENSIS IN WINES Contreras, A; Salinas, F.; Ganga A.; Martínez C Article ISI SCOPUS JOURNAL OF RAPID METHODS AND AUTOMATION IN MICROBIOLOGY (2008)


Genomic and transcriptional profiling of fermentative vigor in laboratory lager yeast hybrid Cubillos, Francisco; Salinas, Francisco Proyecto (2022)
Combining synthetic biology approaches for the reversible and simultaneous transcriptional control of multiple metabolic genes in yeast Salinas, Francisco Proyecto (2021)
Exploiting the wild genetic diversity of Saccharomyces cerevisiae for wine production Salinas, Francisco Proyecto 2020-2024 (2020)
A synthetic biology approach for functional characterization of genes acquired by Horizontal Gene Transfer (HGT) in yeasts FONDECYT (11170158) Proyecto 2017-2020 Inv. Responsable
Adquisición de un sistema de control automatizado de biorreactores Biostat B, para realizar investigación orientada a la industria de alimentos nacional en la Universidad de Santiago de Chile FONDEQUIP (EQM170052) Proyecto 2017-2019 Inv. Responsable
Control de propiedades biotecnológicas e industriales de levaduras mediante interruptores optogenéticos Fundación COPEC-UC (2016.R.740) Proyecto 2017-2018 Coinvestigador(a)
Esfuerzo colaborativo internacional para la caracterización funcional de genes adquiridos por transferencia horizontal en levaduras PCI (REDI170239) Proyecto 2017-2019 Inv. Responsable
Instituto Milenio de Biología Integrativa (iBio) Iniciativa Científica Milenio (ICM-MINECON-IBIO) Proyecto 2017-2022 Investigador(a)
A SYNTHETIC RED-LIGHT TOGGLE SWITCH TO CONTROL GENE EXPRESSION AND MODULATE CIRCADIAN REGULATION IN NEUROSPORA CRASSA. FONDECYT (3150156) Proyecto 2014-2017 Inv. Responsable
Generating a very large yeast diploid population with sequenced genomes for complex traits analysis European BIOFLAVOUR COST Action (COST-STSM-FA0907-14234) Proyecto 2013-2013 Investigador(a)
Postdoctorado Becas Chile=> The Genetics Basis of Cancer Drugs Resistance in Yeast PFCHA (74130015) Proyecto 2013-2014 Inv. Responsable
DOCTORADO EN CIENCIAS M/MICROBIOLOGIA (CONJUNTO CON UCH) PFCHA (24100036) Proyecto 2010-2012 Inv. Responsable
Pasantía Doctoral Becas Chile=> Asociación entre fenotipos enológicos y el genotipo de cepas vínicas de Saccharomyces cerevisiae PFCHA (75100010) Proyecto 2010-2011 Inv. Responsable
DOCTORADO EN CIENCIAS M/MICROBIOLOGIA (CONJUNTO CON UCH) PFCHA (21080179) Proyecto 2008-2012 Inv. Responsable