Latorre_mauricio_01.jpg_thumb90

Mauricio Alejandro Latorre Mora

Profesor Asociado

UNIVERSIDAD DE O'HIGGINS

Rancagua, Chile

Líneas de Investigación


Biotechnology and Systems Biology of pathogen and biomining microorganism.

Educación

  •  Licenciado en Ingeniería en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Doctorado en Ciencias, mención Biología Molecular, Celular y Neurociencias, UNIVERSIDAD DE CHILE. Chile, 2013
  •  Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Profesor Adjunto Part Time

    UNIVERSIDAD DE CHILE

    INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS

    Santiago, Chile

    2014 - A la fecha

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE O'HIGGINS

    CIENCIAS DE LA INGENIERIA

    Rancagua, Chile

    2017 - A la fecha

  •   INVESTIGADOR ASOCIADO Part Time

    UNIVERSIDAD DE CHILE

    Centro de Regulación del Genoma

    Santiago, Chile

    2017 - A la fecha

  •   INVESTIGADOR ASOCIADO Part Time

    CENTRO DE MODELAMIENTO MATEMATICO

    CIENCIAS FISICAS Y MATEMATICAS

    SANTIAGO, Chile

    2016 - A la fecha

Experiencia Profesional

  •   Investigador asociado Part Time

    CMM - Universidad de Chile

    Santiago, Chile

    2006 - A la fecha

  •   Instructor y Capacitador Part Time

    CMS Consultores

    Santiago, Chile

    2006 - 2006

  •   Investigador Part Time

    FONDAP Nº15090007

    Santiago, Chile

    2011 - A la fecha

  •   Ayudante Part Time

    Universidad de Chile

    Santiago, Chile

    2006 - 2006

  •   Ayudante Part Time

    Universidad de Chile

    Santiago, Chile

    2007 - 2007

  •   Ayudante Part Time

    Universidad de Chile

    Santiago, Chile

    2013 - 2013

  •   Profesor Adjunto Part Time

    Universidad de Chile

    Santiago, Chile

    2017 - A la fecha

  •   Profesor Asociado Full Time

    Universidad de O'Higgins

    Rancagua, Chile

    2017 - A la fecha

  •   Editor Other

    Frontiers journal

    Estados Unidos

    2021 - A la fecha

  •   Integrante de grupo de evaluación de FONDECYT Other

    ANID

    Chile

    2021 - A la fecha

Formación de Capital Humano


- March 2021 - current. Master's thesis director.
Professional title: Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: non-coding RNA induced by iron in Enterococcus faecalis.
Student: Sebastián Antonio Gómez Contreras.
Current status: Qualifying exam passed.

- March 2021 - current. Director.
Professional title: Biochemist, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Characterization of ncRNA related to Copper response in Enterococcus faecalis.
Student: Jorge Torres Robles.
Current status: Qualifying exam passed.

- April 2020 - current. Director.
Professional title: Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Transcriptional regulation of NFATc4 / CREB5, and its relationship with the development of cardiac hypertrophy in an in vitro model.
Student: Juan Francisco Silva Agüero.
Current status: Qualifying exam passed.

- June 2020 - current. Associated.
Professional title: Doctor in Pharmacology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Estradiol in the pathogenesis of pulmonary arterial hypertension (HPA): Role of estrogenic activity and hormonal metabolism on smooth arterial muscle cells.
Student: Emanuel Guajardo Correa.
Current status: Qualifying exam passed.

- April 2020 - current. Director.
Professional title: Master in Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Transcriptional regulation of NFATc4 / CREB5, and its relationship with the development of cardiac hypertrophy in an in vitro model.
Student: Juan Francisco Silva Agüero.
Current status: Qualifying exam passed.

- April 2020 - current. Director.
Professional title: Biochemist, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Transcriptional regulation of NFATc4 / CREB5, and its relationship with the development of cardiac hypertrophy in an in vitro model.
Student: Juan Francisco Silva Agüero.
Current status: Qualifying exam passed.

- August 2018 - March 2019. Director.
Professional title: Biochemist, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Memory title: Iron deficiency and subsequent metal reinforcement produces changes in the structure of the intestinal microbiome of Drosophila melanogaster.
Student: Gabriel Gálvez Jiménez.
Current status: Passed, rating 7.0.

- March 2017 - October 2017. Master's thesis director.
Academic degree: Master in Engineering Sciences, mention in Applied Mathematics, Faculty of Physical Sciences and Mathematics, University of Chile.
Thesis title: Mathematical model of copper homeostasis in bacteria.
Student: Martín Ríos Wilson.
Current status: Pass, score 7.0.

- May 2010 - December 2010. Director.
Professional title: Nutritionist, Faculty of Health Sciences, Universidad de Playa Ancha.
Title of the report: Copper Nutrigenomics: Transcriptional study of genes that encode components of the generation of GSH and analysis of viability against changes in the availability of glucose in human lymphocytes exposed to copper.
Former student: Natalia Quiroz Silva.
Current status: Pass, score 7.0.

- May 2010 - December 2010. Director.
Professional title: Nutritionist, Faculty of Health Sciences, Universidad de Playa Ancha.
Title of the report: Copper Nutrigenomics: Transcriptional study of genes that encode components of the generation of GSH and analysis of viability against changes in the availability of glucose in human lymphocytes exposed to copper.
Former student: Nicole Rivas Meneses.
Current status: Pass, score 7.0.


Difusión y Transferencia


I. Link to the Community

- September 26, 2020. Radio Program. Current situation of the Pandemic in the O'Higgins region.
Institution: Welcome Radio, University of O'Higgins
Location: Rancagua, Chile.
Attendees: Radio program.
Topic: Laboratory of Bioengineering and detection of COVID19 in the region.
Objective: Share the experience of the Laboratory in the context of the pandemic and explain the current detection methods for the diagnosis of COVID-19.

- August 18, 2020. Press release. La Tercera newspaper.
Institution: Diario La Tercera, University of O'Higgins, Seremi de Salud.
Place: National, Chile.
Assistants: Online.
Report: O'Higgins State University stands out in the detection of Covid-19 at the national level
Objective: To highlight the work carried out by the Bioengineering Laboratory in the framework of the pandemic.

- July 04, 2020. Television note. TVN Regional O'Higgins - 24 hours.
Institution: Regional TVN, University of O'Higgins, Seremi de Salud.
Place: Region of the Liberator Bernardo O'Higgins, Chile.
Attendees: Online and live newscast.
Topic: Bioengineering Laboratory - COVID19 Diagnosis at the University of O'Higgins.
Objective: Present at a regional level the SARS-Cov2 detection capabilities of the Bioengineering Laboratory of the University of O'Higgins.

- April 24, 2020. PAR Explora Norte. Chat.
Institution: PAR Explora Norte.
Location: Santiago, Chile.
Attendees: Digital broadcasting medium (200 participants).
Talk entitled: The importance of metals in Chile.
Objective: Disseminate basic and application knowledge on concepts of iron nutrition and copper mining processes in Chile.

- March 2020. Television program. TVN Explorers Capsule.
Institution: National Television of Chile, University of O'Higgins, Center for Mathematical Modeling.
Location: Rancagua, Chile.
Attendees: Open television, cable and web platforms.
Topic: Work in Biomining Center for Mathematical Modeling (CMM) and FIC Project.
Objective: Disseminate the work carried out in Tailings in collaboration with the CMM, the University of O'Higgins, Minera Valle Central and the Regional Government.

- May 2-4, 2019. Mining Table. Member of the central discussion table.
Institution: Rancagua International Fair 2019 (FIRAN2019) and CODELCO.
Location: Rancagua, Chile.
Attendees: 300 people.
Topic: Mining and the participation of the University.
Objective: Disseminate the work in Mining and Biotechnology that is being carried out at the University of O'Higgins.

- December 13-14, 2018. Talk. International Symposium on Integrative Bioinformatics SIBI 2018.
Institution: FONDAP Center for Advanced Studies of Chronic Diseases (ACCDIS) and University of Chile.
Location: Santiago, Chile.
Attendees: 60 people.
Talk entitled: Genome scale networks in Enterococcus faecalis.
Objective: Disseminate my work and current line of research developed at the University of O’Higgins University.

- October 26, 2018. Talk. Cycle of Seminars in Bioinformatics and Computational Biology.
Institution: FONDAP Center for Advanced Studies of Chronic Diseases (ACCDIS)
Place: Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Attendees: 50 people.
Talk titled: Systems Biology in Bacteria.
Objective: Disseminate my work and current line of research developed at the University of O’Higgins University.

- September 2018 - Current. Scientific Advisor Explora
Institution: Bernardo O'Higgins Mining Technological Institute.
Location: Rancagua, 6th region, Chile.
Project title: Copper bioaccumulation in Chlorophytum comosum.
Responsible Professor: Darko Soto.
Objective: Scientific advice to the group of 4 students led by Professor Soto for the development of his research project. The project was presented in the Science week organized by the University of O'Higgins and later selected among the best regional works to be presented at the national level by Explora.

- August 30, 2017. Talk PAR Explora O'Higgins. Rapporteur.
Institution: Liceo Eduardo Charme.
Location: San Fernando, 6th region, Chile.
Attendees: Middle IV students (200 participants).
Talk entitled: The importance of metals in Chile.
Objective: Disseminate basic and application knowledge on concepts of iron nutrition and copper mining processes in Chile.
Current status: The chat is part of the Explore database.

II. International meetings

- Gálvez, G., Latorre, M. Déficit y posterior reforzamiento de hierro afectan la homeostasis de cobre y zinc en Drosophila melanogaster. First International Symposium of Food, Nutrition, Physical Fitness and Health. Santiago, Chile. 29 Marzo 2019.

- Gálvez, G., Latorre, M. Déficit y posterior reforzamiento de hierro afectan la homeostasis de cobre y zinc en Drosophila melanogaster. First International Symposium of Food, Nutrition, Physical Fitness and Health. Santiago, Chile. 29 Marzo 2019.

- Latorre, M., Quenti, D., Singh, K.V., Murray, B.E., Maass, A., Cambiazo, V. The role of Fur in the transcriptional and iron homeostatic response of Enterococcus faecalis. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Budinich, M., Latorre, M., Mendoza, S., Cortés, M.P., Eveillard, D., Siegel, A., Maass, A. Multi objective metabolic modeling for optimal growth of Acidithiobacillus ferrooxidans Wenelen and Sulfobacillus thermosulfidooxidans Cutipay. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Ríos, M., Maass, A., Latorre, M. Mathematical modeling of metal homeostasis interplay between copper and iron. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Aite, M., Belcour, A., Markov, G., Dittami, D., Latorre, M. Siegel, A. Tool for genome comparison at metabolic scale. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Frioux, C., Fremy. E., Trottier, C., Latorre, M., Siegel, A. Scalable and exhaustive screening of metabolic functions carried out by microbial consortia. ALAM2018. Santiago, Chile. 13-16 Noviembre 2018.

- Latorre, M. Transcriptional and metabolic regulatory network in Enterococcus faecalis. II Workshop on Systems Biology Chile-France. Valparaíso, Chile. 7-9 Noviembre 2018.

- Panesso, D., Latorre, M., Rincon, S., Miller, W., Diaz, L., Reyes, J., Rios, R., Ardila, J., Carvajal, L.P., Arias, C.A. The LiaR regulon of Daptomycin-resistant Enterococcus faecium. IDSA 2017. San Diego, Estados Unidos. 4-8 Octubre 2017.

- Latorre, M. A System Biology approach to identify putative new targets involved in antibiotic resistance in Enterococcus faecalis. Molecular Basis of Infectious Diseases (MBID) Retreat. Houston, Estados Unidos. 31 Marzo 2017.

- Rojas, C., Mandakovic, D., Maldonado, J., Latorre, M., Cabrera, P., Cambiazo, V., González, M. Structure and interaction patterns of soil microbial communities along an altitudinal pH gradient in the Atacama Desert. ISME. Montreal, Canada. 21-25 Agosto 2016.

- Rincon, S., Panesso, D., Latorre, M., Appel, T., Reyes, J., Tran, T.T., Arias, C.A. Transcriptional Analysis of the liaFSR cluster in Daptomycin resistant Enterococcus faecalis. ASM Microbe 2016-ICAAC 2016. Boston, Estados Unidos. 16 - 20 Junio 2016.

- Diaz, L., Reyes, J., Narechania, A., Rios, R., Munita, J.M., Tran, T.T., Panesso, D., Deikus, G., Sebra, C., Planet, P.J., Bhardwaj, P., Ryan, C., Latorre, M., Palmer, K., Arias, C.A. Genome-Wide Transcriptional Analysis of LiaFSR-mediated Daptomycin Resistance (DAP-R) in Enterococcus faecalis (Efs). ICC2015. Londres, Inglaterra. 8-12 Junio 2015.

- Latorre, M., Cortés, M.P, Travisany, D., Budinich, M., Aravena, A., Parada, P., González, M., Maass, A. Global transcriptional responses of Acidithiobacillus ferrooxidans Wenelen under different sulfide minerals. IBS2015. Bali, Indonesia. 5 - 9 Octubre 2015.

- Latorre, M., González, M., Maass, A. Identification of common and specific cellular processes transcriptionally activated during copper treatments in four biological models. IBS2015. Bali, Indonesia. 5 - 9 Octubre 2015.

- Travisany, D., Cortés, M.P., Latorre, M., Di Genova, A., Budinich, M., Parada, P., González, M., Maass, A. Three genomes of Acidithiobacillus thiooxidans provide insights into adaptation and evolution. IBS2013. 7 - 11. Antofagasta, Chile. Octubre 2013.

- Latorre, M., González, M., Maass, A. Identification of common and specific cellular processes transcriptionally activated during copper treatments in four biological models. 9th International Copper Meeting. Vico Equense, Chile. 5 - 10 Octubre 2014.

- Latorre, M., Arias, C.A., González, M., Maass, A. A System Biology approach to identify putative new targets involved in antibiotic resistance in Enterococcus faecalis. 4th ASM Conference on Enterococci. Cartagena, Colombia. 5-7 Marzo 2014.

- Latorre, M., Budinich, M.., Maturana, D., Maass, A., González, M. Conserved transcriptional regulatory networks in Lactobacillales order species. Plant & Animal Genome XX (PAGXX). San Diego, Estados Unidos. 14-18 Enero 2012.

- Latorre, M., Galloway-Peña, J., Rho, J., Murray, B.E., Maass, A., González, M. Conserved transcriptional regulatory mechanism involved in copper and iron homeostasis in Lactobacillales order species. Fourth International Workshop on Iron and Copper. Pucón, Chile. 30 Noviembre – 3 Diciembre 2011.

- Latorre, M., Rho, J.H., Murray, B.E., Maass, A., González, M. Identification and verification of transcriptional networks involved in iron homeostasis and oxidative stress damage activated by copper in Enterococcus faecalis. TEMA-14: Trace Elements in Man and Animals. Enshi, China. 19 - 24 Septiembre 2011.

- González, M., Latorre, M., Maass, A., Transcriptional regulatory network activated by copper and iron in Enterococcus faecalis. International Workshop on Genomics of Health and Diseases. Natal, Brasil. 12-15 Marzo 2011.

- Latorre, M., Moreno, P., Aravena, A., Cambiazo, V., Maass, A., González, M. In-silico identification and characterization of efflux heavy metals resistance proteins in Acidithiobacillus ferroxidans. Tema 13-Trace Elements in Man and Animals. Pucón, Chile. 9 - 13 Noviembre 2008.

- Zúñiga, A., Latorre, M., Hanna, P., Cambiazo, V. Molecular and functional characterization of RhoGEF3, a regulator of RhoGTPases in Drosophila melanogaster embryos. 4th International Meeting of the Latin American Society of Developmental Biology. Buenos Aires, Argentina. 23-25 Octubre 2006.

- Reyes, A., Latorre, M., Bourgogne, A., Murray, B., González, M. Functional Analysis of a cop-like operon from Enterococcus faecalis. 5th International Copper Meeting: Copper and Related Metals in Biology, Alghero, Italia. 14 - 18 Octubre 2006.

III. International collaborations

- Université de Picardie Jules Verne (Amien, France): Laboratory directed by Dr. Irina Korichneva (MILEAGE project Nº734931).

- CNRS-IRISA-INRIA (Rennes, France): Dyliss Group led by Dr. Anne Siegel (3 articles published together, 2 projects).

- University of Nantes (Nantes, France): Computational Biology Group of Dr. Damien Eveillard (2 articles published together, 2 projects).

- The University of Texas (Houston, USA): Group of "Infectious Diseases" led by Dr. Barbara E. Murray and Dr. Danielle Garsin (6 articles published during the project, 3 projects).

- MD Anderson (Houston, USA): Dra. Sruti DebRoy Group (2 articles published together).

- The University of Alaska Anchorage (Alaska, USA): Dr. Jason Burkhead Group (3 articles published together, 2 projects).

- Federal University of Santa Catarina (Florianópolis, Brazil). Laboratory directed by Dr. Alexandra Latini (COVID19 project N ° COVID0620).

IV. Scientific Societies.

- Active member. Chilean Cell Biology Society (SBCCH), Chile. March 2017-current.

- Founding Partner. Chilean Society of Bioinformatics (SCB), Chile. October 2020 - current.

V. International Journal Reviewer

- Journal: Metallomics (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2017 - current.

- Journal:: Biological Research (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2016 - current.

- Journal: Frontiers in Microbiology (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2018 - current.

- Journal: Plos One (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2017 - current.

- Journal: Journal of Applied Microbiology (ISI / Wos).
Function: Reviewer of scientific articles.
Year: 2018 - current.

VI. International meeting organizer

- Event: III International Symposium on Integrative Bioinformatics SIBI 2019.
Location: Pucón, Chile.
Dates: December 11-13, 2019
Organizers: Universidad de Chile, Universidad de O'Higgins, Regional Government, Universidad Mayor, Universidad de la Frontera, BIOINFO, METROPOLE Digital, CAPES, ACCDiS, Biome.
Attendees: 100 attendees, 15 Universities.
Character: International
Role played: Event organizer. Financing of the FIC2018 project and the University of O'Higgins.
Others: https://es.bioinformaticaintegrativa.cl/

- Event: II Workshop on Systems Biology Chile-France.
Location: Valparaíso, Chile.
Dates: 7-9 November 2018
Organizers: University of O'Higgins, Center for Mathematical Modeling, CNRS-Inria.
Attendees: 30 assistant, 7 Universities.
Character: International
Role played: Event organizer. Financing project PCI 2017-REDESI170193.
Others: http://eventos.cmm.uchile.cl/sysbio2018/

- Event: CRG: 1st Doctoral and Post Doctoral meeting.
Location: Santiago, Chile.
Dates: 7-9 November 2018
Organizers: Universidad de Chile, Pontificia Universidad Católica de Chile, Universidad Andrés Bello.
Attendees: 50 attendees, 5 Universities.
National character.
Role played: Event organizer. Financing Fondap project No. 15090007.


Premios y Distinciones

  •   Annual Fee Scholarship for Graduate Studies

    UNIVERSIDAD DE CHILE

    Chile, 2007

    Academic Award, granted by the Faculty of Sciences, Universidad de Chile, Chile.

  •   PhD Scholarship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2007

    Academic Award

  •   Experimental Support for PhD thesys

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2010

    Academic Award

  •   Support for International Research Internships - MECESUPUCH0713

    UNIVERSIDAD DE CHILE

    Chile, 2012

    Academic Award.

  •   Support for International Research Internships - MECESUPUCH0713

    UNIVERSIDAD DE CHILE

    Chile, 2011

    Academic Award.

  •   Support for International Research Internships

    Vicerrectoría de Asuntos Académicos

    Chile, 2011

    Academic Award granted by Vicerrectoría de Asuntos Académicos

  •   PhD Scholarship

    FONDAP N°15090007

    Chile, 2011

    Academic Award

  •   Assistance Grant Year 2011, First Place Poster

    Tema14 congress

    China, 2011

    Research Award. First place Poster Presentation Tema14 congress, Enshi, China.

  •   National congress assistance

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Academic Award.

  •   Post-doc Scholarship Year 2013-2014

    UNIVERSIDAD DE CHILE

    Chile, 2013

    Academic Award

  •   Reconocimiento Red de Laboratorios Universitarios

    ministerio de ciencia tecnología conocimiento e innovación

    Chile, 2020

    Director del Laboratorio de Bioingeniería Unidad de Detección y Análisis - Región de O'Higgins. Laboratorio Universitario activo destinado al apoyo diario para diagnóstico de COVI19 por PCR.


 

Article (42)

Genome-scale metabolic models of Microbacterium species isolated from a high altitude desert environment
Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus
Integration of Biological Networks for Acidithiobacillus thiooxidans Describes a Modular Gene Regulatory Organization of Bioleaching Pathways
Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis
Chronic copper treatment prevents the liver critical balance transcription response induced by acetaminophen
Comparative Transcriptome Profiling in a Segregating Peach Population with Contrasting Juiciness Phenotypes
Generation and robustness of Boolean networks to model Clostridium difficile infection
The Combined Effect of Cold and Copper Stresses on the Proliferation and Transcriptional Response of Listeria monocytogenes
Altered zinc balance in the Atp7b?/? mouse reveals a mechanism of copper toxicity in Wilson disease
Codon usage bias reveals genomic adaptations to environmental conditions in an acidophilic consortium
Structure and co-occurrence patterns in microbial communities under acute environmental stress reveal ecological factors fostering resilience
Synthesis and Antibacterial Activity of Metal(loid) Nanostructures by Environmental Multi-Metal(loid) Resistant Bacteria and Metal(loid)-Reducing Flavoproteins
The Role of Fur in the Transcriptional and Iron Homeostatic Response of Enterococcus faecalis
Traceability, reproducibility and wiki-exploration for a-la-carte reconstructions of genome-scale metabolic models
A Multi-Serotype Approach Clarifies the Catabolite Control Protein A Regulon in the Major Human Pathogen Group A Streptococcus
A Multi-Serotype Approach Clarifies the Catabolite Control Protein A Regulon in the Major Human Pathogen Group A Streptococcus.
Different Transcriptional Responses from Slow and Fast Growth Rate Strains of Listeria monocytogenes Adapted to Low Temperature
Different Transcriptional Responses from Slow and Fast Growth Rate Strains of Listeria monocytogenes Adapted to Low Temperature.
Different Transcriptional Responses from Slow and Fast Growth Rate Strains of Listeria monocytogenes Adapted to Low Temperature.
Global transcriptional responses of Acidithiobacillus ferrooxidans Wenelen under different sulfide minerals.
Identification of reference genes for quantitative real-time PCR studies in human cell lines under copper and zinc exposure.
Putative bacterial interactions from metagenomic knowledge with an integrative systems ecology approach.
Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.
The bioleaching potential of a bacterial consortium.
Complete genome sequence of Microbacterium sp. CGR1, bacterium tolerant to wide abiotic conditions isolated from the Atacama Desert.
Complete genome sequence of Microbacterium sp. CGR1, bacterium tolerant to wide abiotic conditions isolated from the Atacama Desert.
Interplay between copper and zinc homeostasis through the transcriptional regulator Zur in Enterococcus faecalis.
Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease.
Synergistic effect of copper and low temperature over Listeria monocytogenes.
Transcriptional activation of glutathione pathways and role of glucose homeostasis during copper imbalance.
A new genome of Acidithiobacillus thiooxidans provides insights into adaptation to a bioleaching environment.
A new genome of Acidithiobacillus thiooxidans provides insights into adaptation to a bioleaching environment.
Enterococcus faecalis reconfigures its transcriptional regulatory network activation at different copper levels.
Enterococcus faecalis reconfigures its transcriptional regulatory network activation at different copper levels.
Genome wide identification of Acidithiobacillus ferrooxidans (ATCC 23270) transcription factors and comparative analysis of ArsR and MerR metal regulators.
Genome wide identification of Acidithiobacillus ferrooxidans (ATCC 23270) transcription factors and comparative analysis of ArsR and MerR metal regulators.
Genomic and SNP Analyses Demonstrate a Distant Separation of the Hospital and Community-Associated Clades of Enterococcus faecium.
Transcriptomic response of Enterococcus faecalis to iron excess.
CutC is induced late during copper exposure and can modify intracellular copper content in Enterococcus faecalis.
Genome-wide transcriptome analysis of the adaptive response of Enterococcus faecalis to copper exposure.
Genome-wide transcriptome analysis of the adaptive response of Enterococcus faecalis to copper exposure.
CutC is induced late during copper exposure and can modify intracellular copper content in Enterococcus faecalis.

BookSection (3)

Chapter 2: Copper.
Chapter 1. Biological aspects of copper.
Chapter 28th: Regulación Transcriptional de Metales Trazas.

ConferencePoster (13)

Mathematical modeling of metal homeostasis interplay between copper and iron.
Multi objective metabolic modeling for optimal growth of Acidithiobacillus ferrooxidans Wenelen and Sulfobacillus thermosulfidooxidans Cutipay.
Scalable and exhaustive screening of metabolic functions carried out by microbial consortia.
The role of Fur in the transcriptional and iron homeostatic response of Enterococcus faecalis.
Tool for genome comparison at metabolic scale.
Transcriptional and metabolic regulatory network in Enterococcus faecalis.
A System Biology approach to identify putative new targets involved in antibiotic resistance in Enterococcus faecalis
Structure and interaction patterns of soil microbial communities along an altitudinal pH gradient in the Atacama Desert.
The LiaR regulon of Daptomycin-resistant Enterococcus faecium.
Transcriptional Analysis of the liaFSR cluster in Daptomycin resistant Enterococcus faecalis
A. Global transcriptional responses of Acidithiobacillus ferrooxidans Wenelen under different sulfide minerals.
Genome-Wide Transcriptional Analysis of LiaFSR-mediated Daptomycin Resistance (DAP-R) in Enterococcus faecalis (Efs).
Identification of common and specific cellular processes transcriptionally activated during copper treatments in four biological models.

Proyecto (36)

Systems Biology Center for the study of extremophile communities from mining tailings.
Laboratorio de diagnóstico Universidad de O’Higgins.
Marcadores Metabólicos de Pronóstico de Severidad para Pacientes Covid-19.
Laboratorio Biominero para la Región de O'Higgins
Non-coding RNA global transcriptional regulatory network activated by metals in Enterococcus faecalis.
RCAN1 trisomy and the control of PINK1 levels in the survival of human Down's syndrome induced pluripotent stem cells (iPSC) and iPSC-derived cardiomyocytes
Transcriptional Networks for Mitochondrial Dynamics related to Human Cardiomyocyte Dysfunction.
Entendiendo la complejidad metabólica y nutricional de frutos en poscosecha: una perspectiva integradora desde la Biología de Sistemas
Estudio de especies bacterianas nativas de importancia nacional mediante estrategias de Biología de Sistemas.
Estudio de especies bacterianas nativas de importancia nacional mediante estrategias de Biología de Sistemas
Microelements in Life Expectancy and Aging
Microelements in Life Expectancy and Aging –MILEAGE
Synergistic transcriptional response of Listeria monocytogenes to low temperature and copper.
Synergistic transcriptional response of Listeria monocytogenes to low temperature and copper
Center of Mathematical Modeling (CMM) BASAL N°PFB03.
FONDECYT N°11150679. Role of Fur in the systemic response of Enterococcus faecalis and its impact on in vivo infectiveness under different nutritional status of iron.
FONDECYT N°1151384. Metal metabolism in soil bacterial communities from an extreme environment: A comparative genomics analysis.
Fondo de Equipamiento Científico y Tecnológico (FONDEQUIP) N°EQM140121. Total Reflection X-ray Fluorescence (TXRF).
METAL METABOLISM IN SOIL BACTERIAL COMMUNITIES FROM AN EXTREME ENVIRONMENT=> A COMPARATIVE GENOMICS ANALYSIS.
Role of Fur in the systemic response of Enterococcus faecalis and its impact on in vivo infectiveness under different nutritional status of iron.
Total Reflection X-ray Fluorescence (TXRF)
Center for Genome Regulation
Center for Genome Regulation (CGR) FONDAP 15090007.
Gene regulatory network of iron metabolism in E. faecalis=> functional analysis of Fur, PerR and Zur regulon
Center for Mathematical Modeling (CMM)
FONDECYT Nº1110427: Gene regulatory network of iron metabolism in E. faecalis: functional analysis of Fur, PerR and Zur regulon.
Genómica funcional de nectarines=> plataforma para la competitividad nacional en exportación de frutas. Part II
Estudio de los cambios transcripcionales Inducidos por la Exposición a Cobre en Enterococcus faecalis
FONDECYT Nº1071083: Estudio de los cambios transcripcionales Inducidos por la Exposición a Cobre en Enterococcus faecalis: Análisis Funcional e Identificación de Redes de Regulación.
FONDEF G07I1001: Genómica funcional de nectarines: plataforma para la competitividad nacional en exportación de frutas. Part II.
FONDEF NºD04I-1257: Desarrollo de una capacidad científico-tecnológica en modelación matemática y simulación para el control de redes biológicas en procesos productivos. Aplicación a la Biolixiviación bacteriana.
Caracterización Funcional de Genes Diferencialmente Expresados Durante la Gastrulación de Drosophila
Identificación y Análisis de Perfiles de Expresión de los Genes Asociados a la Adaptación Celular a Cobre.
Proyecto FONDECYT Nº1050235: Caracterización Funcional de Genes Diferencialmente Expresados Durante la Gastrulación de Drosophila.
Desarrollo de una capacidad científico-tecnológica en modelación matemática y simulación para el control de redes biológicas en procesos productivos. Aplicación a la Biolixiviación bacteriana.
FONDECYT Nº1030618: Identificación y Análisis de Perfiles de Expresión de los Genes Asociados a la Adaptación Celular a Cobre.
71
Mauricio Latorre

Profesor Asociado

INGENIERIA

UNIVERSIDAD DE O'HIGGINS

Rancagua, Chile

3
Veronica Cambiazo

Profesora titular

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

3
Dante Travisany

Profesor Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

3
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

3
JONATHAN MALDONADO

Postdoc CONICYT

Dpto. Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
DINKA MANDAKOVIC

Assistant Professor

GEMA Center

Universidad Mayor

Santiago, Chile

2
Alexis Gaete

Postdoctorado

Instituto de Nutrición y Tecnmología de los Alimentos (INTA)

Universidad de Chile

Santiago, Chile

2
Sebastian Mendoza

Jefe de operaciones

STICTA

santiago, Chile

2
Felipe Maza

Analista ETESA

Departamento de Investigación del Cáner

Fundación Arturo López Pérez

Santiago, Chile

2
Alejandro Maass

Main Researcher

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

1
Christian Hodar

ASSISTANT PROFESSOR

BIOINFORMATICS & GENEXPRESSION LAB - INTA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Angelica Reyes

Profesor Asociado

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Talia del Pozo

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
MIGUEL ARREDONDO

Académico, Profesor Titular

Unidad de Nutrición Humana

Universidad de Chile, INTA

Santiago, Chile

1
Miguel Allende

Director

Biología

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Navarrete

Associate Professor

INTA

Universidad de Chile

Santiago, Chile

1
Sandra Diaz

Associate Professor

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Ana Quesille

Investigadora Postdoctoral

Universidad del Desarrollo

Santiago, Chile

1
Rodrigo Gutierrez

Full Professor

Molecular Genetics & Microbiology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Claudia Rojas

Associate professor

Instituto de Ciencias Agroalimentarias, Animales y Amientalesas y Veterinarias

Universidad de O'Higgins

San Fernando, Chile

1
Eric Goles

Full Professor

Facultad de Ingeniería y Ciencias

Universidad Adolfo Ibáñez

Santiago, Chile

1
Ariel Orellana

Profesor Titular

Centro de Biotecnologia Vegetal

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Patricio Hinrichsen

Investigador

INIA CENTRO REGIONAL LA PLATINA

Santiago, Chile

1
Leonardo Pavez

Profesor Asociado

Instituto de Ciencias Naturales

Universidad de Las Américas

Santiago, Chile

1
Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

1
Nicolas Loira

CTO AlicantoLabs

Escuela de Negocios

Universidad Adolfo Ibáñez

Santiago, Chile

1
Victor Aliaga

Postdoctorante

Universidad de O'Higgins

Santiago, Chile

1
Sergio Navarrete

Full Profesor

Ecología

Pontificia Universidad Católica de Chile

Las CRuces, Chile

1
Claudio Latorre

Full Professor

Ecology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ángel Parra

Asistente de Investigación

INTA

Universidad de Chile

Santiago, Chile

1
Francisca Díaz

Investigadora postdoctoral

Genética molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Claudia Muñoz

Investigador

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Esteban Vargas

Asesor Científico

Transferencia Tecnológica

CEDENNA

Santiago, Chile